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编 号：F151655
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CAS No: 1402-82-0
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生物活性：
Amphomycin is a lipopeptide antibiotic that inhibits peptidoglycan synthesis and blocks cell wall development. Amphomycin exhibits potent antibacterial activities against methicillin-resistant S. aureus (MRSA), vancomycin-resistant enterococci (VRE), penicillin-gentamicin-erythromycin-resistant S. pneumonia, and linezolid-quinupristin-dalfopristin-resistant enterococci.
体内研究：
Amphomycin (50 mg/kg; p.o.; single) shows low oral availability and (5-10mg/kg; i.v.; single) exhibits a long half-life (5.2-8.0 h in mice and 4.6-7.1 h in rats).
体外研究：
Amphomycin (40 μ g/mL; 60 min) leads S. aureus to exhibit cell wall thinning and Park’s nucleotide accumulation.
Amphomycin is a lipopeptide antibiotic that inhibits peptidoglycan synthesis and blocks cell wall development. Amphomycin exhibits potent antibacterial activities against methicillin-resistant S. aureus (MRSA), vancomycin-resistant enterococci (VRE), penicillin-gentamicin-erythromycin-resistant S. pneumonia, and linezolid-quinupristin-dalfopristin-resistant enterococci.
体内研究：
Amphomycin (50 mg/kg; p.o.; single) shows low oral availability and (5-10mg/kg; i.v.; single) exhibits a long half-life (5.2-8.0 h in mice and 4.6-7.1 h in rats).
体外研究：
Amphomycin (40 μ g/mL; 60 min) leads S. aureus to exhibit cell wall thinning and Park’s nucleotide accumulation.
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