产品
编 号：F016303
分子式：C24H32N4O3
分子量：424.54
分子式：C24H32N4O3
分子量：424.54
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CAS No: 1037837-27-6
产品详情
生物活性：
ARN14494 is a potent and selective serine palmitoyltransferase (SPT) inhibitor, with an IC50 of 27.3 nM. ARN14494 affects the CNS in terms of anti-inflammation and neuroprotection. ARN14494 protects neurons from β-amyloid 1-42-induced neurotoxicity through a variety of mechanisms, including anti-oxidation, anti-apoptosis, and anti-inflammation. ARN14494 can be used for Alzheimer’s disease research.
体外研究：
ARN14494 (1-10 μM) 对小鼠原代星形胶质细胞SPT活性的抑制作用呈浓度依赖性。ARN14494 (10 μM, 24 h) 降低Aβ1-42诱导的脑皮层星形胶质细胞神经酰胺和二氢神经酰胺水平。ARN14494 (10 μM, 0-24 h) 抑制原代星形胶质细胞培养中寡聚 Aβ 诱导的促炎分子(包括 NO、TNF-α、IL1β、TGF1β、促炎酶INOS和COX-2) 的产生。ARN14494 对皮质神经元 Aβ 神经毒性和 caspase-3 激活的影响。
ARN14494 is a potent and selective serine palmitoyltransferase (SPT) inhibitor, with an IC50 of 27.3 nM. ARN14494 affects the CNS in terms of anti-inflammation and neuroprotection. ARN14494 protects neurons from β-amyloid 1-42-induced neurotoxicity through a variety of mechanisms, including anti-oxidation, anti-apoptosis, and anti-inflammation. ARN14494 can be used for Alzheimer’s disease research.
体外研究：
ARN14494 (1-10 μM) 对小鼠原代星形胶质细胞SPT活性的抑制作用呈浓度依赖性。ARN14494 (10 μM, 24 h) 降低Aβ1-42诱导的脑皮层星形胶质细胞神经酰胺和二氢神经酰胺水平。ARN14494 (10 μM, 0-24 h) 抑制原代星形胶质细胞培养中寡聚 Aβ 诱导的促炎分子(包括 NO、TNF-α、IL1β、TGF1β、促炎酶INOS和COX-2) 的产生。ARN14494 对皮质神经元 Aβ 神经毒性和 caspase-3 激活的影响。
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