产品
编 号：F150609
分子式：C23H18Cl2F4N2O5S
分子量：581.36
分子式：C23H18Cl2F4N2O5S
分子量：581.36
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
结构图
CAS No: 1398609-39-6
产品详情
生物活性：
Sarolaner (PF-6450567) is an orally active and broad-spectrum ectoparasiticide. Sarolaner is an isoxazoline compound which shows efficacy against fleas and ticks on dogs, with a LC80 value of 0.3 μg/mL against C. felis and a LC100 value of 0.003 μg/mL against O. turicata.
体内研究：
Sarolaner (2.5 mg/kg；一次口服) 对 R. sanguineus 和 D. reticuLatus 显示出 100% 的有效性。 Sarolaner (1.25-5 mg/kg；口服一次) 有效对抗 I. ricinus。Animal Model:Dog infested with R. sanguineus and D. reticulatus
Dosage:2.5 mg/kg
Administration:Oral gavage; 2.5 mg/kg once
Result:Exibited 100% efficacy against R. sanguineus at 48 hours after treatment and also exhibited 98.0% efficacy againstD. reticulatus.
Animal Model:Dog infested with I. ricinus
Dosage:1.25, 2.5 and 5 mg/kg
Administration:Oral gavage; 1.25, 2.5 and 5 mg/kg once
Result:Exibited 100% efficacy against I. ricinus at all doses until 7 days, and provided over 99.3% reduction against subsequent re-infestations until 57 days at dose of 5.0 and 2.5 mg/kg.
体外研究：
Sarolaner (450 nM-1 mM；5 分钟) 通过 γ-氨基丁酸 (GABA) 诱导的电流抑制 CfRDL-A285 和 CfRDL-S285 受体。
Sarolaner (PF-6450567) is an orally active and broad-spectrum ectoparasiticide. Sarolaner is an isoxazoline compound which shows efficacy against fleas and ticks on dogs, with a LC80 value of 0.3 μg/mL against C. felis and a LC100 value of 0.003 μg/mL against O. turicata.
体内研究：
Sarolaner (2.5 mg/kg；一次口服) 对 R. sanguineus 和 D. reticuLatus 显示出 100% 的有效性。 Sarolaner (1.25-5 mg/kg；口服一次) 有效对抗 I. ricinus。Animal Model:Dog infested with R. sanguineus and D. reticulatus
Dosage:2.5 mg/kg
Administration:Oral gavage; 2.5 mg/kg once
Result:Exibited 100% efficacy against R. sanguineus at 48 hours after treatment and also exhibited 98.0% efficacy againstD. reticulatus.
Animal Model:Dog infested with I. ricinus
Dosage:1.25, 2.5 and 5 mg/kg
Administration:Oral gavage; 1.25, 2.5 and 5 mg/kg once
Result:Exibited 100% efficacy against I. ricinus at all doses until 7 days, and provided over 99.3% reduction against subsequent re-infestations until 57 days at dose of 5.0 and 2.5 mg/kg.
体外研究：
Sarolaner (450 nM-1 mM；5 分钟) 通过 γ-氨基丁酸 (GABA) 诱导的电流抑制 CfRDL-A285 和 CfRDL-S285 受体。
产品资料
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