产品
编 号：F150040
分子式：C15H24Cl2NO4P
分子量：384.24
分子式：C15H24Cl2NO4P
分子量：384.24
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
360
In-stock
5mg
792
In-stock
10mg
1400
In-stock
25mg
3000
In-stock
50mg
5400
In-stock
结构图
CAS No: 139667-74-6
产品详情
生物活性：
CGP52432 is a GABAB receptor antagonist, with an IC50 of 85 nM.
体内研究：
CGP52432 (10, 30 mg/kg) shows no effect on the total arm entries and total head dips of mice on the elevated-plus maze. CGP52432 (100 nmol/kg, i.v., or 1 nmol/kg, i.c.v.) abolishes the suppressive effects of GABA ( 50 μmol/kg, i.v.) on enhanced renal sympathetic nerve activity (RSNA) during ischaemia, causeing elimination of the renoprotective effects of GABA in rats.
体外研究：
CGP52432 is a GABAB receptor antagonist, with an IC50 of 85 nM, 35- and 100-fold lower than at the receptors regulating somatostatin and glutamate overflow, respectively.
CGP52432 is a GABAB receptor antagonist, with an IC50 of 85 nM.
体内研究：
CGP52432 (10, 30 mg/kg) shows no effect on the total arm entries and total head dips of mice on the elevated-plus maze. CGP52432 (100 nmol/kg, i.v., or 1 nmol/kg, i.c.v.) abolishes the suppressive effects of GABA ( 50 μmol/kg, i.v.) on enhanced renal sympathetic nerve activity (RSNA) during ischaemia, causeing elimination of the renoprotective effects of GABA in rats.
体外研究：
CGP52432 is a GABAB receptor antagonist, with an IC50 of 85 nM, 35- and 100-fold lower than at the receptors regulating somatostatin and glutamate overflow, respectively.
产品资料
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