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编 号：F149868
分子式：C91H117N19O26
分子量：1893.01
分子式：C91H117N19O26
分子量：1893.01
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CAS No: 139570-93-7
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Zoptarelin doxorubicin (AEZS-108; AN-152) is a hybrid anticancer agent, containing Zoptarelin and Doxorubicin. Zoptarelin doxorubicin has been used to research targeting tumors expressing LHRH receptors. Zoptarelin doxorubicin abolishes tumor progression and induces remarkable apoptosis in vitro.
体内研究：
Zoptarelin doxorubicin (AN-152) inhibits tumor growth in glioblastoma xenograft mice.Animal Model:Female nude mice (injected in the flanks with 1×106 glioblastoma U-87 MG cells)
Dosage:413 nM/20g
Administration:i.v.; once weekly; for 6 weeks
Result:Significantly inhibited tumor growth compared to the control.
体外研究：
Zoptarelin doxorubicin (AN-152) inhibits almost 70 % of glioblastoma cell growth, increases almost 250% apoptosis and causes a greater increase in calcein retention.Zoptarelin doxorubicin (AN-152) up-regulates the tumor suppressor and pro-apoptotic p53, and inhibits the expression of the primordial, neuroectodermal stem cell marker, nestin.
Zoptarelin doxorubicin (AEZS-108; AN-152) is a hybrid anticancer agent, containing Zoptarelin and Doxorubicin. Zoptarelin doxorubicin has been used to research targeting tumors expressing LHRH receptors. Zoptarelin doxorubicin abolishes tumor progression and induces remarkable apoptosis in vitro.
体内研究：
Zoptarelin doxorubicin (AN-152) inhibits tumor growth in glioblastoma xenograft mice.Animal Model:Female nude mice (injected in the flanks with 1×106 glioblastoma U-87 MG cells)
Dosage:413 nM/20g
Administration:i.v.; once weekly; for 6 weeks
Result:Significantly inhibited tumor growth compared to the control.
体外研究：
Zoptarelin doxorubicin (AN-152) inhibits almost 70 % of glioblastoma cell growth, increases almost 250% apoptosis and causes a greater increase in calcein retention.Zoptarelin doxorubicin (AN-152) up-regulates the tumor suppressor and pro-apoptotic p53, and inhibits the expression of the primordial, neuroectodermal stem cell marker, nestin.
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