产品
编 号：F149550
分子式：C24H20N6O3
分子量：440.45
分子式：C24H20N6O3
分子量：440.45
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
询价
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50mg
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询价
结构图
CAS No: 139481-59-7
产品详情
生物活性：
Candesartan (CV 11974) is an orally active angiotensin II AT1-Receptor blocker and PPAR-γ agonist. Candesartan has potent and long-lasting antihypertensive effects. Candesartan can be used for the research of hypertension, chronic heart failure (CHF) and Traumatic brain injury (TBI).
体内研究：
Candesartan (腹腔注射；1 mg/kg/天；持续 1、3 或 28 dpi) 具有神经保护作用，可减少神经元损伤、减少损伤体积和小胶质细胞活化、保护 CBF 并改善 TBI 小鼠模型的功能行为。Animal Model:C57BL/6 mice (nine-week-old, male, 22–28?g)
Dosage:1?mg/kg
Administration:i.p.; 1?mg/kg/day; continuously for 1, 3 or 28 dpi.
Result:Reduced the lesion volume after CCI injury by approximately 50%, decreased the number of dying neurons, lessened the number of activated microglial cells, protected cerebral blood flow (CBF), and reduced the expression of the cytokine TGF?1 while increasing expression of TGFB3.Showed good motor skills on the rotarod 3 days after injury, and improved performance in the Morris water maze 4 weeks after injury.
Candesartan (CV 11974) is an orally active angiotensin II AT1-Receptor blocker and PPAR-γ agonist. Candesartan has potent and long-lasting antihypertensive effects. Candesartan can be used for the research of hypertension, chronic heart failure (CHF) and Traumatic brain injury (TBI).
体内研究：
Candesartan (腹腔注射；1 mg/kg/天；持续 1、3 或 28 dpi) 具有神经保护作用，可减少神经元损伤、减少损伤体积和小胶质细胞活化、保护 CBF 并改善 TBI 小鼠模型的功能行为。Animal Model:C57BL/6 mice (nine-week-old, male, 22–28?g)
Dosage:1?mg/kg
Administration:i.p.; 1?mg/kg/day; continuously for 1, 3 or 28 dpi.
Result:Reduced the lesion volume after CCI injury by approximately 50%, decreased the number of dying neurons, lessened the number of activated microglial cells, protected cerebral blood flow (CBF), and reduced the expression of the cytokine TGF?1 while increasing expression of TGFB3.Showed good motor skills on the rotarod 3 days after injury, and improved performance in the Morris water maze 4 weeks after injury.
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