产品
编 号:F148550
分子式:C23H24N6O
分子量:400.48
产品类型
结构图
CAS No: 1392816-46-4
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生物活性:
SI-113 is a SGK1 inhibitor, with an IC50 of 600 nM. SI113 induces autophagy.
体外研究:
SI-113 exhibits IC50 values of 10.5, 14.4 and 10.7 μM in GIN8, GIN28 and GCE28 GBM cells.SI-113 induces significant increases in caspase-3/7 activation in all GBM cell lines.SI-113 induces autophagy and synergizes with quinacrine in hindering the growth of human glioblastoma multiforme cells.