产品
编 号：F148172
分子式：C16H15N7O2
分子量：337.34
分子式：C16H15N7O2
分子量：337.34
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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5mg
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10mg
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50mg
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100mg
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200mg
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结构图
CAS No: 139180-30-6
产品详情
生物活性：
ZM241385 is a potent, high affinity and selective adenosine A2a receptor (A2AR) antagonist with a Ki value of 1.4 nM.
体内研究：
ZM241385 (0.2 μg/mouse, 0.4 μg/mouse; intraperitoneal injection; every day; for 11 weeks; female C57BL/6 WT mice) treatment decreases tumor volume, activates CD8+ T cells and reduces the frequency of splenic MDSC.Animal Model:Female C57BL/6 WT mice received 4-nitroquinoline-N-oxide
Dosage:0.2 μg/mouse, 0.4 μg/mouse
Administration:Intraperitoneal injection; every day; for 11 weeks
Result:Decreased tumor volume, activates CD8+ T cells and reduces the frequency of splenic MDSC.
体外研究：
ZM241385 (1 μM; 24-48 hours; PC12 cells) treatment reverses the phenomenon that A2AR agonist CGS21680 significantly upregulates A2AR mRNA and protein levels.
ZM241385 is a potent, high affinity and selective adenosine A2a receptor (A2AR) antagonist with a Ki value of 1.4 nM.
体内研究：
ZM241385 (0.2 μg/mouse, 0.4 μg/mouse; intraperitoneal injection; every day; for 11 weeks; female C57BL/6 WT mice) treatment decreases tumor volume, activates CD8+ T cells and reduces the frequency of splenic MDSC.Animal Model:Female C57BL/6 WT mice received 4-nitroquinoline-N-oxide
Dosage:0.2 μg/mouse, 0.4 μg/mouse
Administration:Intraperitoneal injection; every day; for 11 weeks
Result:Decreased tumor volume, activates CD8+ T cells and reduces the frequency of splenic MDSC.
体外研究：
ZM241385 (1 μM; 24-48 hours; PC12 cells) treatment reverses the phenomenon that A2AR agonist CGS21680 significantly upregulates A2AR mRNA and protein levels.
产品资料
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