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编 号：F147153
分子式：C27H41N9O8
分子量：619.67
分子式：C27H41N9O8
分子量：619.67
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CAS No: 138949-73-2
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生物活性：
Osteostatin, a fragment of parathyroid hormone-related protein (PTHrP) 107-111, promotes bone repair in animal models of bone defects and prevents bone erosion in inflammatory arthritis, inhibits collagen-induced arthritis and inhibits osteoclastic bone resorption directly. Osteostatin can be used for inflammation and immunology research.
体内研究：
Osteostatin (80 或 120 μg/kg；在疾病发作后每天皮下注射，持续 13 天) 降低关节炎的严重程度及软骨和骨降解。Animal Model:Collagen-induced arthritis in male DBA/1 mice
Dosage:80 or 120 μg/kg
Administration:After the onset of disease s.c. every day for 13 days
Result:Reduced serum IgG2a levels as well as T cell activation, with the downregulation of RORγt+CD4+ T cells and upregulation of FoxP3+CD8+ T cells in lymph nodes. Decreased the levels of key cytokines, such as interleukin (IL)-1β, IL-2, IL-6, IL-17, and tumor necrosis factor-α in mice paws, whereas enhanced IL-10.
体外研究：
Osteostatin (100，250，500 nM，7-9 天) 以浓度依赖的方式降低破骨细胞的分化。Osteostatin (100，250，500 nM，7 天) 降低组织蛋白酶 K、破骨细胞相关 Ig 样受体 (OSCAR) 和NFATc1 的 mRNA 水平。Osteostatin (100，250，500 nM，2 天) 抑制破骨细胞分化中主转录因子 NFATc1 的核转位。Osteostatin (0.1-100 nM, 2 天) 显著促进骨细胞 MC3T3-E1 的生长。
Osteostatin, a fragment of parathyroid hormone-related protein (PTHrP) 107-111, promotes bone repair in animal models of bone defects and prevents bone erosion in inflammatory arthritis, inhibits collagen-induced arthritis and inhibits osteoclastic bone resorption directly. Osteostatin can be used for inflammation and immunology research.
体内研究：
Osteostatin (80 或 120 μg/kg；在疾病发作后每天皮下注射，持续 13 天) 降低关节炎的严重程度及软骨和骨降解。Animal Model:Collagen-induced arthritis in male DBA/1 mice
Dosage:80 or 120 μg/kg
Administration:After the onset of disease s.c. every day for 13 days
Result:Reduced serum IgG2a levels as well as T cell activation, with the downregulation of RORγt+CD4+ T cells and upregulation of FoxP3+CD8+ T cells in lymph nodes. Decreased the levels of key cytokines, such as interleukin (IL)-1β, IL-2, IL-6, IL-17, and tumor necrosis factor-α in mice paws, whereas enhanced IL-10.
体外研究：
Osteostatin (100，250，500 nM，7-9 天) 以浓度依赖的方式降低破骨细胞的分化。Osteostatin (100，250，500 nM，7 天) 降低组织蛋白酶 K、破骨细胞相关 Ig 样受体 (OSCAR) 和NFATc1 的 mRNA 水平。Osteostatin (100，250，500 nM，2 天) 抑制破骨细胞分化中主转录因子 NFATc1 的核转位。Osteostatin (0.1-100 nM, 2 天) 显著促进骨细胞 MC3T3-E1 的生长。
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