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编 号:F146579
分子式:C30H30ClN7O4
分子量:588.06
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生物活性:
DYRKs-IN-1 is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor with IC50s of 5 nM and 8 nM for DYRK1A and DYRK1B, respectively. DYRKs-IN-1 has antitumor activity.

体外研究:
DYRKs-IN-1 (compound 30) increases the cellular potency against the human colon tumor cell line SW 620 with an EC50 of 27 nM. DYRKs-IN-1 (Example 183) is a potent DYRKs inhibitor.
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