产品
编 号：F146402
分子式：C27H44ClNO8
分子量：546.09
分子式：C27H44ClNO8
分子量：546.09
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
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询价
50mg
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询价
100mg
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结构图
CAS No: 138605-00-2
产品详情
生物活性：
NKH477 (Colforsin dapropate hydrochloride) directly activates the catalytic unit of adenylate cyclase and increases intracellular cAMP. NKH477 is a forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 exerts an antiproliferative effect in vivo with an altered cytokine profile to inhibit the acute rejection of rat orthotopic lung allografts.
体内研究：
NKH477 (Colforsin dapropate hydrochloride) (orally; 1-3 mg/kg/day; days 3 and 5) prolonged lung allograft survival in a dose dependent manner.Animal Model:Specific-pathogen-free inbred male Lewis rats (LEW) weighing 250 to 280 g
Dosage:1, 2 or 3 mg/kg/day
Administration:Orally; daily; Days 3 and 5
Result:Prolonged lung allograft survival in a dose dependent manner.
NKH477 (Colforsin dapropate hydrochloride) directly activates the catalytic unit of adenylate cyclase and increases intracellular cAMP. NKH477 is a forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 exerts an antiproliferative effect in vivo with an altered cytokine profile to inhibit the acute rejection of rat orthotopic lung allografts.
体内研究：
NKH477 (Colforsin dapropate hydrochloride) (orally; 1-3 mg/kg/day; days 3 and 5) prolonged lung allograft survival in a dose dependent manner.Animal Model:Specific-pathogen-free inbred male Lewis rats (LEW) weighing 250 to 280 g
Dosage:1, 2 or 3 mg/kg/day
Administration:Orally; daily; Days 3 and 5
Result:Prolonged lung allograft survival in a dose dependent manner.
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