产品
编 号：F146252
分子式：C13H18O7
分子量：286.28
分子式：C13H18O7
分子量：286.28
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5g
询价
询价
10g
询价
询价
结构图
CAS No: 138-52-3
产品详情
生物活性：
Salicin is a natural COX inhibitor.
体内研究：
Salicin (D(-)-Salicin) (35, 70, 140 μM) markedly inhibits the LPS-induced pathological changes. MPO activity in LPS-induced lung tissue is significantly increased compare with control group. However,Salicin (35, 70, 140 μM) markedly inhibits this change. Pretreatment withSalicin inhibits LPS-induced activation of JNK, ERK, p38/MAPK and p65 in a dose-dependent manner.
体外研究：
Significant down regulation of PGE2, the enzymatic product of COX2, to 76% in lysate and 70% in supernatant is observed with Salicin 10 μM treatment in COLO cells when compare to the COLO control. This is accompanied with a minimal COX1 inhibition to 91% of the CCD control on the genetic level. Treatment with Salicin 1 μM decreases colon cancer cell proliferation rates from 144% to 113% at 24 hours and 187% to 130% at 48 hours, with 10 μM decreasing proliferation rates to108% at 24 hours and 119% at 48 hours. The concentrations of TNF-α, IL-1β and IL-6 of LPS-induced cells pretreated with 0.07, 0.14 and 0.28 μM Salicin are significant reduced compare with LPS group.
Salicin is a natural COX inhibitor.
体内研究：
Salicin (D(-)-Salicin) (35, 70, 140 μM) markedly inhibits the LPS-induced pathological changes. MPO activity in LPS-induced lung tissue is significantly increased compare with control group. However,Salicin (35, 70, 140 μM) markedly inhibits this change. Pretreatment withSalicin inhibits LPS-induced activation of JNK, ERK, p38/MAPK and p65 in a dose-dependent manner.
体外研究：
Significant down regulation of PGE2, the enzymatic product of COX2, to 76% in lysate and 70% in supernatant is observed with Salicin 10 μM treatment in COLO cells when compare to the COLO control. This is accompanied with a minimal COX1 inhibition to 91% of the CCD control on the genetic level. Treatment with Salicin 1 μM decreases colon cancer cell proliferation rates from 144% to 113% at 24 hours and 187% to 130% at 48 hours, with 10 μM decreasing proliferation rates to108% at 24 hours and 119% at 48 hours. The concentrations of TNF-α, IL-1β and IL-6 of LPS-induced cells pretreated with 0.07, 0.14 and 0.28 μM Salicin are significant reduced compare with LPS group.
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