产品
编 号：F144991
分子式：C7H5ClF3NS5
分子量：355.89
分子式：C7H5ClF3NS5
分子量：355.89
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
结构图
CAS No: 1381769-23-8
产品详情
生物活性：
TC-2153 is a selective inhibitor of striatal-enriched protein tyrosine phosphatase (STEP), with psychotropic activity and low acute toxicity. TC-2153 increases the expression of brain-derived neurotropic factor (BDNF) in the brain. And it decreases MAOA and 5-HT1A receptors mRNA level in midbrain. TC-2153 also inhibits 5-HT2A receptor-mediated signaling.
体内研究：
慢性 TC-2153 处理: TC-2153 (20 mg/kg; 腹腔注射; 每天 1 次，连续 7 天) 显示抗抑郁类效果，不改变运动，探索活动和焦虑情况。 急性 TC-2153 处理: TC-2153 (10 mg/kg和20 mg/kg; 单次剂量) 抑制小鼠体内 5-HT2A 受体的功能活性。Animal Model:SPF-state adult mouse males
Dosage:10 mg/kg and 20 mg/kg; with or without 1 mg/kg DOI i.p. at 3 h after final treatment
Administration:Oral gavage or intraperitoneal injection; single dose or once daily for 7 d
Result:Showed antidepressant-like effect in the forced swim test without any adverse side effects on locomotor activity, anxiety, exploration, motor skill and obsessive-compulsive-like behavior.Both acute and chronic methods inhibited the functional activity of 5-HT2A receptors.
体外研究：
TC-2153 (10 μM; 3 h) 减少皮层和海马神经元体外培养中 DOI (HY-103124) 诱导的 c-fos 阳性神经元百分比。
TC-2153 is a selective inhibitor of striatal-enriched protein tyrosine phosphatase (STEP), with psychotropic activity and low acute toxicity. TC-2153 increases the expression of brain-derived neurotropic factor (BDNF) in the brain. And it decreases MAOA and 5-HT1A receptors mRNA level in midbrain. TC-2153 also inhibits 5-HT2A receptor-mediated signaling.
体内研究：
慢性 TC-2153 处理: TC-2153 (20 mg/kg; 腹腔注射; 每天 1 次，连续 7 天) 显示抗抑郁类效果，不改变运动，探索活动和焦虑情况。 急性 TC-2153 处理: TC-2153 (10 mg/kg和20 mg/kg; 单次剂量) 抑制小鼠体内 5-HT2A 受体的功能活性。Animal Model:SPF-state adult mouse males
Dosage:10 mg/kg and 20 mg/kg; with or without 1 mg/kg DOI i.p. at 3 h after final treatment
Administration:Oral gavage or intraperitoneal injection; single dose or once daily for 7 d
Result:Showed antidepressant-like effect in the forced swim test without any adverse side effects on locomotor activity, anxiety, exploration, motor skill and obsessive-compulsive-like behavior.Both acute and chronic methods inhibited the functional activity of 5-HT2A receptors.
体外研究：
TC-2153 (10 μM; 3 h) 减少皮层和海马神经元体外培养中 DOI (HY-103124) 诱导的 c-fos 阳性神经元百分比。
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