产品
编 号：F144747
分子式：C31H31NO3
分子量：465.58
分子式：C31H31NO3
分子量：465.58
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
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询价
结构图
CAS No: 1380548-02-6
产品详情
生物活性：
SR10067 is a potent, selective and brain penetrant REV-ERB agonist. SR10067 has high affinity for Rev-Erbβ and Rev-Erbα with IC50 values of 160 nM and 170 nM, respectively. SR10067 can be used for the research of metabolic diseases and neuropsychiatric disorders.
体内研究：
SR10067 (i.p.; 30 mg/kg) has good pharmacokinetic properties in mouse.Animal Model:Mice
Dosage:30 mg/kg
Administration:i.p.
Result:Remained above the IC50 of the receptor in plasma and brain concentrations.Suppressed the circadian rhythm of Npas2 gene expression in the mouse hypothalamus in a single injection and had a dose-dependent effect on reduction in nocturnal wheel running activity. Induced wakefulness and reduced SWS and REM sleep and displayed high anxiolytic activity.
体外研究：
SR10067 has high affinity for Rev-Erbβ and Rev-Erbαwith IC50 values are 160 and 170 nM, respectively.
SR10067 is a potent, selective and brain penetrant REV-ERB agonist. SR10067 has high affinity for Rev-Erbβ and Rev-Erbα with IC50 values of 160 nM and 170 nM, respectively. SR10067 can be used for the research of metabolic diseases and neuropsychiatric disorders.
体内研究：
SR10067 (i.p.; 30 mg/kg) has good pharmacokinetic properties in mouse.Animal Model:Mice
Dosage:30 mg/kg
Administration:i.p.
Result:Remained above the IC50 of the receptor in plasma and brain concentrations.Suppressed the circadian rhythm of Npas2 gene expression in the mouse hypothalamus in a single injection and had a dose-dependent effect on reduction in nocturnal wheel running activity. Induced wakefulness and reduced SWS and REM sleep and displayed high anxiolytic activity.
体外研究：
SR10067 has high affinity for Rev-Erbβ and Rev-Erbαwith IC50 values are 160 and 170 nM, respectively.
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