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编 号：F142377
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5mg
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10mg
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CAS No: 1374853-91-4
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生物活性：
Pembrolizumab (MK-3475) is a humanized IgG4 antibody inhibiting the programmed cell death 1 (PD-1) receptor, used in cancer immunotherapy.
体内研究：
Pembrolizumab inhibits tumor size in A549 xenograft mice pretreated by pressure.Animal Model:Six-week-old male BALB/c athymic nude mice
Dosage:5 mg/kg
Administration:Pembrolizumab (5 mg/kg; Intravenous injection; Once)
Result:Reduced tumorigenesis in αROR1-CAR T cells and co-cultured with A549 cells.
体外研究：
Pembrolizumab (MK-3475) increases the secretion of cytokines IFN-γ, TNF-α and the apoptotic cell death of A549 cells.Pembrolizumab improves the αROR1-CAR T-mediated cytotoxicity, and reduces tumorigenesis in the co-cultured αROR1-CAR T and A549 cells by blocking PD-1::PD-L1 interaction in αROR1-CAR T cells.
Pembrolizumab (MK-3475) is a humanized IgG4 antibody inhibiting the programmed cell death 1 (PD-1) receptor, used in cancer immunotherapy.
体内研究：
Pembrolizumab inhibits tumor size in A549 xenograft mice pretreated by pressure.Animal Model:Six-week-old male BALB/c athymic nude mice
Dosage:5 mg/kg
Administration:Pembrolizumab (5 mg/kg; Intravenous injection; Once)
Result:Reduced tumorigenesis in αROR1-CAR T cells and co-cultured with A549 cells.
体外研究：
Pembrolizumab (MK-3475) increases the secretion of cytokines IFN-γ, TNF-α and the apoptotic cell death of A549 cells.Pembrolizumab improves the αROR1-CAR T-mediated cytotoxicity, and reduces tumorigenesis in the co-cultured αROR1-CAR T and A549 cells by blocking PD-1::PD-L1 interaction in αROR1-CAR T cells.
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