产品
编 号：F142367
分子式：C14H16F3N7
分子量：339.32
分子式：C14H16F3N7
分子量：339.32
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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2mg
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5mg
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10mg
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25mg
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50mg
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结构图
CAS No: 1374828-69-9
产品详情
生物活性：
GNE0877 is a highly selective, orally active and brain-penetrant LRRK2 inhibitor with an IC50 of 3 nM and a Ki of 0.7 nM. GNE0877 can be used for the research of neuroscience.
体内研究：
GNE0877 (10 and 50 mg/kg; i.p. once) inhibits LRRK2 Ser1292 autophosphorylation.Animal Model:BAC transgenic mice expressing human LRRK2 protein with the G2019S Parkinson’s disease mutation
Dosage:10 and 50 mg/kg
Administration:Intraperitoneal injection; 10 and 50 mg/kg once
Result:Tration-dependently inhibited Ser1292 autophosphorylation with an IC50 of 3 nM.
体外研究：
GNE0877 (1 μM; 10-30 min) shows good cellular potency in human liver microsomes and hepatocytes.
GNE0877 is a highly selective, orally active and brain-penetrant LRRK2 inhibitor with an IC50 of 3 nM and a Ki of 0.7 nM. GNE0877 can be used for the research of neuroscience.
体内研究：
GNE0877 (10 and 50 mg/kg; i.p. once) inhibits LRRK2 Ser1292 autophosphorylation.Animal Model:BAC transgenic mice expressing human LRRK2 protein with the G2019S Parkinson’s disease mutation
Dosage:10 and 50 mg/kg
Administration:Intraperitoneal injection; 10 and 50 mg/kg once
Result:Tration-dependently inhibited Ser1292 autophosphorylation with an IC50 of 3 nM.
体外研究：
GNE0877 (1 μM; 10-30 min) shows good cellular potency in human liver microsomes and hepatocytes.
产品资料
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