产品
编 号：F141314
分子式：C16H14F3N5O
分子量：349.31
分子式：C16H14F3N5O
分子量：349.31
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
10mg
267
In-stock
50mg
640
In-stock
100mg
832
In-stock
结构图
CAS No: 137234-62-9
产品详情
生物活性：
Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes.
体内研究：
Voriconazole (5 -20 mg/kg；口服 21 天) 以剂量依赖方式延长生存期。Voriconazole (40 mg/kg/day) 可降低肺部的真菌负荷。Animal Model:Male specific-pathogen-free BALB/cByJ mice
Dosage:1, 5, 20 mg/kg/day
Administration:P.o. once daily for 21 days
Result:Improved survival in a dose-response fashion, with median survival times (MSTs) of 21, 28, and 35 days with doses of 1, 5, and 20 mg/kg, respectively.
体外研究：
Voriconazole 对 S. apiospermum 和 C. neoformans 具有很强的活性，MIC 分别为 0.5 μg/mL 和 0.125-0.25 μg/mL。 Voriconazole 抑制细胞色素 P450 (CYP) 依赖性酶 14-α-甾醇脱甲基酶，从而破坏细胞膜并阻止真菌生长。
Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes.
体内研究：
Voriconazole (5 -20 mg/kg；口服 21 天) 以剂量依赖方式延长生存期。Voriconazole (40 mg/kg/day) 可降低肺部的真菌负荷。Animal Model:Male specific-pathogen-free BALB/cByJ mice
Dosage:1, 5, 20 mg/kg/day
Administration:P.o. once daily for 21 days
Result:Improved survival in a dose-response fashion, with median survival times (MSTs) of 21, 28, and 35 days with doses of 1, 5, and 20 mg/kg, respectively.
体外研究：
Voriconazole 对 S. apiospermum 和 C. neoformans 具有很强的活性，MIC 分别为 0.5 μg/mL 和 0.125-0.25 μg/mL。 Voriconazole 抑制细胞色素 P450 (CYP) 依赖性酶 14-α-甾醇脱甲基酶，从而破坏细胞膜并阻止真菌生长。
产品资料
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