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编 号：F139706
分子式：C14H19ClN6O
分子量：322.79
分子式：C14H19ClN6O
分子量：322.79
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CAS No: 136777-48-5
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生物活性：
Abacavir hydrochloride is a competitive, orally active nucleoside reverse transcriptase inhibitor. Abacavir hydrochloride can inhibits the replication of HIV. Abacavir hydrochloride shows anticancer activity in prostate cancer cell lines. Abacavir hydrochloride can trespass the blood-brain-barrier and suppresses telomerase activity.
体内研究：
Abacavir hydrochloride (100 and 200 mg/kg, p.o.; 4 h) dose-dependently promotes thrombus formation.Abacavir hydrochloride (50 mg/kg/d; i.p.; 14 d) with 0.1 mg/kg/d Decitabine (HY-A0004) enhances survival of high-risk medulloblastoma-bearing mice.Animal Model:Male mice (9-weeks old, 22-30 g) - wild-type (WT) C57BL/6 or homozygous knockout (P2rx7 KO, B6.129P2-P2rx7tm1Gab/J)
Dosage:Route 1: 2.5, 5, and 7.5 μg/mL, 100 μLRoute 2: 100 and 200 mg/kg
Administration:Intrascrotal or oral administration for 4 h
Result:Dose-dependently promoted thrombus formation.
Animal Model:NSGTM mice, patient-derived xenograft (PDX) cells of non-WNT/non-SHH, Group 3 and of SHH/ TP53-mutated medulloblastoma
Dosage:50 mg/kg/d with 0.1 mg/kg/d Decitabine
Administration:Intraperitoneal injection, daily for 14 days
Result:Inhibited tumor growth and enhanced mouse survival.
体外研究：
Abacavir hydrochloride (15 and 150 μM, 0-120 h) inhibits cell growth, affects cell cycle progression, induces senescence and modulates LINE-1 mRNA expression in prostate cancer cell lines.Abacavir hydrochloride (15 and 150 μM, 18 h) significantly reduces cell migration and inhibits cell invasion.Abacavir hydrochloride induces fat apoptosis.
Abacavir hydrochloride is a competitive, orally active nucleoside reverse transcriptase inhibitor. Abacavir hydrochloride can inhibits the replication of HIV. Abacavir hydrochloride shows anticancer activity in prostate cancer cell lines. Abacavir hydrochloride can trespass the blood-brain-barrier and suppresses telomerase activity.
体内研究：
Abacavir hydrochloride (100 and 200 mg/kg, p.o.; 4 h) dose-dependently promotes thrombus formation.Abacavir hydrochloride (50 mg/kg/d; i.p.; 14 d) with 0.1 mg/kg/d Decitabine (HY-A0004) enhances survival of high-risk medulloblastoma-bearing mice.Animal Model:Male mice (9-weeks old, 22-30 g) - wild-type (WT) C57BL/6 or homozygous knockout (P2rx7 KO, B6.129P2-P2rx7tm1Gab/J)
Dosage:Route 1: 2.5, 5, and 7.5 μg/mL, 100 μLRoute 2: 100 and 200 mg/kg
Administration:Intrascrotal or oral administration for 4 h
Result:Dose-dependently promoted thrombus formation.
Animal Model:NSGTM mice, patient-derived xenograft (PDX) cells of non-WNT/non-SHH, Group 3 and of SHH/ TP53-mutated medulloblastoma
Dosage:50 mg/kg/d with 0.1 mg/kg/d Decitabine
Administration:Intraperitoneal injection, daily for 14 days
Result:Inhibited tumor growth and enhanced mouse survival.
体外研究：
Abacavir hydrochloride (15 and 150 μM, 0-120 h) inhibits cell growth, affects cell cycle progression, induces senescence and modulates LINE-1 mRNA expression in prostate cancer cell lines.Abacavir hydrochloride (15 and 150 μM, 18 h) significantly reduces cell migration and inhibits cell invasion.Abacavir hydrochloride induces fat apoptosis.
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