产品
编 号：F139106
分子式：C31H42N6O7
分子量：610.7
分子式：C31H42N6O7
分子量：610.7
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
结构图
CAS No: 136553-81-6
产品详情
生物活性：
BQ-123 is a potent and selective endothelin A (ETA) receptor antagonist with an IC50 of 7.3 nM and a Ki of 25 nM. BQ-123 inhibits endothelin-1-mediated proliferation of human pulmonary artery smooth muscle cells and lowers blood pressure in different rat models of hypertension.
体内研究：
持续输注 BQ-123（每分钟 0.16-164 nmol/kg，静脉注射，持续 6 小时）可在自发性高血压大鼠 (SHR) 中产生剂量依赖性平均动脉压降低，剂量为 16 nmol 时获得最大降低/千克每分钟。BQ-123（3 mg/kg；静脉注射；在戊四唑 (PTZ) 前 15 分钟给予）在 PTZ（50 mg/kg；腹腔注射）+BQ-123 组中很大程度上阻止癫痫发作的形成和扩散[ 5]。Animal Model:Male Wistar albino rats
Dosage:3 mg/kg
Administration:Intravenous injection; given 15 minutes before PTZ
Result:Number of rats with major seizure decreased.
BQ-123 is a potent and selective endothelin A (ETA) receptor antagonist with an IC50 of 7.3 nM and a Ki of 25 nM. BQ-123 inhibits endothelin-1-mediated proliferation of human pulmonary artery smooth muscle cells and lowers blood pressure in different rat models of hypertension.
体内研究：
持续输注 BQ-123（每分钟 0.16-164 nmol/kg，静脉注射，持续 6 小时）可在自发性高血压大鼠 (SHR) 中产生剂量依赖性平均动脉压降低，剂量为 16 nmol 时获得最大降低/千克每分钟。BQ-123（3 mg/kg；静脉注射；在戊四唑 (PTZ) 前 15 分钟给予）在 PTZ（50 mg/kg；腹腔注射）+BQ-123 组中很大程度上阻止癫痫发作的形成和扩散[ 5]。Animal Model:Male Wistar albino rats
Dosage:3 mg/kg
Administration:Intravenous injection; given 15 minutes before PTZ
Result:Number of rats with major seizure decreased.
产品资料
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