产品
编 号：F138808
分子式：C22H28N4O6
分子量：444.48
分子式：C22H28N4O6
分子量：444.48
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CAS No: 136470-65-0
产品详情
生物活性：
Banoxantrone (AQ4N), as a prototype hypoxia selective cytotoxin, can be reduced to AQ4, a potent topoisomerase II inhibitor. Banoxantrone selectively kills hypoxic cells via an iNOS-dependent mechanism. Banoxantrone shows a potent cytotoxicity and hypoxia-selective effect enhanced by radiation.
体内研究：
Banoxantrone (200 mg/kg; 腹腔注射; 单剂量) 在 BDF 小鼠中显著抑制T50/80肿瘤，并诱导细胞损伤。
体外研究：
Banoxantrone (20 μM; 90 min) 选择性诱导缺氧的 T50/80 肿瘤细胞发生损伤。
Banoxantrone (AQ4N), as a prototype hypoxia selective cytotoxin, can be reduced to AQ4, a potent topoisomerase II inhibitor. Banoxantrone selectively kills hypoxic cells via an iNOS-dependent mechanism. Banoxantrone shows a potent cytotoxicity and hypoxia-selective effect enhanced by radiation.
体内研究：
Banoxantrone (200 mg/kg; 腹腔注射; 单剂量) 在 BDF 小鼠中显著抑制T50/80肿瘤，并诱导细胞损伤。
体外研究：
Banoxantrone (20 μM; 90 min) 选择性诱导缺氧的 T50/80 肿瘤细胞发生损伤。
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