产品
编 号:F138250
分子式:C20H17FN2O3
分子量:352.36
产品类型
结构图
CAS No: 1363281-27-9
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产品详情
生物活性:
JNJ-46778212 (VU 0409551) is an mGlu5 positive allosteric modulator with an EC50 of 260 nM.
体内研究:
In oral brain/plasma studies, JNJ-46778212 displays excellent CNS penetration. JNJ-46778212 enhances NMDAR function and rescues long-term potentiation in hippocampal slices obtained from SR?/? mice. The administration of JNJ-46778212 to SR?/? mice reverses their deficits in several neuroplasticity signaling pathways and improves their contextual fear memory.