产品
编 号：F138110
分子式：C9H18N2OS
分子量：202.32
分子式：C9H18N2OS
分子量：202.32
产品类型
规格
价格
是否有货
结构图
CAS No: 136259-20-6
产品详情
生物活性：
P32/98 a potent inhibitor of dipeptidyl peptidase IV with a Ki value of 130 nM. P32/98 improves glucose tolerance, insulin sensitivity and β-cell responsiveness in fatty Zucker rat model.
体内研究：
P32/98 (25 mg/kg; i.g.; once daily) long-time treatment significantly improves the glucose tolerance in Zucker diabetic fatty rats, a model of IGT (impaired glucose tolerance).Animal Model:Zucker diabetic fatty rat
Dosage:25 mg/kg
Administration:Oral gavage; once daily
Result:Significantly improved the glucose tolerance in Zucker diabetic fatty rats.
体外研究：
GLP-1 acts function of stimulation of glucose dependent insulin secretion and induction of satiety feelings, and DPPIV is the major renal catabolic pathway for GLP-1 in vivo.P32/98 hemifumarate, together with 200 pM GLP-1, (10 μM; 3 h) shows no significant inhibition of sodium re-absorption in porcine proximal tubular cells.P32/98 (10 μM; 96 h) does not influence the mRNA expression of GLP-1R, DPPIV, Na+/H+ exchanger isoform 3 (NHE3), sodium-dependent glucose transporter slc5a1, slc5a2 (SGLT1, 2).
P32/98 a potent inhibitor of dipeptidyl peptidase IV with a Ki value of 130 nM. P32/98 improves glucose tolerance, insulin sensitivity and β-cell responsiveness in fatty Zucker rat model.
体内研究：
P32/98 (25 mg/kg; i.g.; once daily) long-time treatment significantly improves the glucose tolerance in Zucker diabetic fatty rats, a model of IGT (impaired glucose tolerance).Animal Model:Zucker diabetic fatty rat
Dosage:25 mg/kg
Administration:Oral gavage; once daily
Result:Significantly improved the glucose tolerance in Zucker diabetic fatty rats.
体外研究：
GLP-1 acts function of stimulation of glucose dependent insulin secretion and induction of satiety feelings, and DPPIV is the major renal catabolic pathway for GLP-1 in vivo.P32/98 hemifumarate, together with 200 pM GLP-1, (10 μM; 3 h) shows no significant inhibition of sodium re-absorption in porcine proximal tubular cells.P32/98 (10 μM; 96 h) does not influence the mRNA expression of GLP-1R, DPPIV, Na+/H+ exchanger isoform 3 (NHE3), sodium-dependent glucose transporter slc5a1, slc5a2 (SGLT1, 2).
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备