产品
编 号：F137987
分子式：C14H18O3
分子量：234.29
分子式：C14H18O3
分子量：234.29
产品类型
规格
价格
是否有货
结构图
CAS No: 136171-87-4
产品详情
生物活性：
Lobetyol is a natural compound that can be isolated from Lobelia chinensis. Lobetyol induces apoptosis and cell cycle arrest in MKN45 cells. Lobetyol shows anti-virus, anti-inflammation and anti-tumor activity. Lobetyol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
体内研究：
Lobetyol (0-10 mg/kg，每3天一次)抑制 MKN45 裸鼠模型中的肿瘤生长。Animal Model:BALB/C nude mice (6 weeks-old, injected intraperitoneally with MKN45 cells)
Dosage:0, 2, 5, 10 mg/kg
Administration:Once per 3 days
Result:Suppressed tumor growth in MKN45 nude models. The protein levels of Ki67 in MKN45 cells were significantly decreased. Meanwhile, cleaved-caspase-3 positive MKN45 cells were found increased with the tendency of lobetyol concentrations in the study in vivo.
体外研究：
Lobetyol (0-100 μg/mL, 0-48 h) 在 MKN45 细胞中导致剂量和时间依赖性增殖抑制。Lobetyol (0-100 μg/mL, 48 h) 以时间和剂量依赖的方式诱导 MKN45 细胞细胞凋亡和细胞周期停滞。Lobetyol (0-100 μg/mL, 48 h) 增加 Bax、P53 的表达水平，降低 Bcl-2 的表达水平。
Lobetyol is a natural compound that can be isolated from Lobelia chinensis. Lobetyol induces apoptosis and cell cycle arrest in MKN45 cells. Lobetyol shows anti-virus, anti-inflammation and anti-tumor activity. Lobetyol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
体内研究：
Lobetyol (0-10 mg/kg，每3天一次)抑制 MKN45 裸鼠模型中的肿瘤生长。Animal Model:BALB/C nude mice (6 weeks-old, injected intraperitoneally with MKN45 cells)
Dosage:0, 2, 5, 10 mg/kg
Administration:Once per 3 days
Result:Suppressed tumor growth in MKN45 nude models. The protein levels of Ki67 in MKN45 cells were significantly decreased. Meanwhile, cleaved-caspase-3 positive MKN45 cells were found increased with the tendency of lobetyol concentrations in the study in vivo.
体外研究：
Lobetyol (0-100 μg/mL, 0-48 h) 在 MKN45 细胞中导致剂量和时间依赖性增殖抑制。Lobetyol (0-100 μg/mL, 48 h) 以时间和剂量依赖的方式诱导 MKN45 细胞细胞凋亡和细胞周期停滞。Lobetyol (0-100 μg/mL, 48 h) 增加 Bax、P53 的表达水平，降低 Bcl-2 的表达水平。
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备