产品
编 号:F137491
分子式:C18H15N5O6S2
分子量:461.47
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10mM*1mL in DMSO
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5mg
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10mg
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25mg
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50mg
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100mg
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生物活性:
Necrosulfonamide is a necroptosis inhibitor acting by selectively targeting the mixed lineage kinase domain-like protein (MLKL). Necrosulfonamide prevents MLKL-RIP1-RIP3 necrosome complex from interacting with its downstream effectors. MLKL is a critical substrate of RIP3 during the induction of necrosis.

体外研究:
Necrosulfonamide 特异性阻断 RIP3 激活的下游坏死。Necrosulfonamide 通过阻断其 N 端 CC 结构域功能来抑制 MLKL 介导的坏死。
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