产品
编 号：F137026
分子式：C19H16F4N4O
分子量：392.35
分子式：C19H16F4N4O
分子量：392.35
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 1358575-02-6
产品详情
生物活性：
TP-024 (FTBMT) is a selective GPR52 agonist with an EC50 of 75 nM. TP-024 has antipsychotic and procognitive properties.
体内研究：
TP-024 (FTBMT) (30 mg/kg, 90 minutes) exhibits antipsychotic-like activity without causing catalepsy in mice.TP-024 (3 or 10 mg/kg, 48 hours) improves recognition and spatial working memory in rats.TP-024 (3, 10, 30 mg/kg, 2 hours) stimulates neuronal activity in brain regions related to cognition.Animal Model:Male Long-Evans rats (9 weeks old)
Dosage:10 mg/kg
Administration:Oral, 1 hour before memory test
Result:A 1-hour pretreatment with FTBMT (10 mg/kg, p.o.) significantly decreases the number of memory errors induced by MK-801.
Animal Model:Male ICR mice (7 to 8 weeks old)
Dosage:3–30 mg/kg
Administration:Oral, 60 minutes before s.c. administration of MK-801
Result:FTBMT increases phospho-DARPP32 levels in the NAc slices.
体外研究：
TP-024 (FTBMT) (0.1-10 μM) increases intracellular cAMP levels in CHO cells expressing human, mouse, or rat GPR52, with pEC50s of 7.03, 6.85, and 6.87, respectively.
TP-024 (FTBMT) is a selective GPR52 agonist with an EC50 of 75 nM. TP-024 has antipsychotic and procognitive properties.
体内研究：
TP-024 (FTBMT) (30 mg/kg, 90 minutes) exhibits antipsychotic-like activity without causing catalepsy in mice.TP-024 (3 or 10 mg/kg, 48 hours) improves recognition and spatial working memory in rats.TP-024 (3, 10, 30 mg/kg, 2 hours) stimulates neuronal activity in brain regions related to cognition.Animal Model:Male Long-Evans rats (9 weeks old)
Dosage:10 mg/kg
Administration:Oral, 1 hour before memory test
Result:A 1-hour pretreatment with FTBMT (10 mg/kg, p.o.) significantly decreases the number of memory errors induced by MK-801.
Animal Model:Male ICR mice (7 to 8 weeks old)
Dosage:3–30 mg/kg
Administration:Oral, 60 minutes before s.c. administration of MK-801
Result:FTBMT increases phospho-DARPP32 levels in the NAc slices.
体外研究：
TP-024 (FTBMT) (0.1-10 μM) increases intracellular cAMP levels in CHO cells expressing human, mouse, or rat GPR52, with pEC50s of 7.03, 6.85, and 6.87, respectively.
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