产品
编 号：F015177
分子式：C25H20N4O2
分子量：408.45
分子式：C25H20N4O2
分子量：408.45
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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1mg
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 103420-77-5
产品详情
生物活性：
Devazepide (L-364,718) is a potent, competitive, selective and orally active nonpeptide antagonist of cholecystokinin (CCK) receptor, with IC50s of 81 pM, 45 pM and 245 nM for rat pancreatic, bovine gallbladder and guinea pig brain CCK receptors, respectively. Devazepide (L-364,718) is effective for gastrointestinal disorders.
体内研究：
Devazepide (oral gavage; 4 mg/kg; twice per day) significantly accelerates cholesterol crystallization and crystal growth to microlithiasis, and the formation of gallstones in mice.Devazepide (intraperitoneal?injection; 0.1-1 mg/kg) has opposite effects on spontaneous locomotor activity, and on caerulein- and apomorphine-induced hypomotility in the mouse.Animal Model:Male C57BL/6J mice
Dosage:4 mg/kg
Administration:Oral gavage; 4 mg/kg; twice per day
Result:Increased susceptibility to gallstone formation by impairing gallbladder emptying function.Disrupted biliary cholesterol metabolism and enhanced intestinal cholesterol absorption in mice.
Devazepide (L-364,718) is a potent, competitive, selective and orally active nonpeptide antagonist of cholecystokinin (CCK) receptor, with IC50s of 81 pM, 45 pM and 245 nM for rat pancreatic, bovine gallbladder and guinea pig brain CCK receptors, respectively. Devazepide (L-364,718) is effective for gastrointestinal disorders.
体内研究：
Devazepide (oral gavage; 4 mg/kg; twice per day) significantly accelerates cholesterol crystallization and crystal growth to microlithiasis, and the formation of gallstones in mice.Devazepide (intraperitoneal?injection; 0.1-1 mg/kg) has opposite effects on spontaneous locomotor activity, and on caerulein- and apomorphine-induced hypomotility in the mouse.Animal Model:Male C57BL/6J mice
Dosage:4 mg/kg
Administration:Oral gavage; 4 mg/kg; twice per day
Result:Increased susceptibility to gallstone formation by impairing gallbladder emptying function.Disrupted biliary cholesterol metabolism and enhanced intestinal cholesterol absorption in mice.
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