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编 号:F015156
分子式:C25H21F4N3O3
分子量:487.45
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10mM*1mL in DMSO
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5mg
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10mg
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25mg
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50mg
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生物活性:
AZD5423 is an inhaled, potent, selective, and non-steroidal glucocorticoid receptor (GR) modulator (SGRM). AZD5423 effectively reduces allergen-induced responses in subjects with mild allergic asthma.

体外研究:
The affinity of AZD5423 to the glucocorticoid receptor is high with an IC50 of 0.9 nM in a radioligand human glucocorticoid receptor assay, and selectivity towards other steroid hormone receptors is >900-fold.
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