产品
编 号:F134648
分子式:C15H13Cl2N3O2
分子量:338.19
产品类型
结构图
CAS No: 1354037-26-5
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产品详情
生物活性:
KH-CB19 is a potent CLK (cdc2-like kinase) inhibitor (CLK1 IC50=19.7 nM; CLK3 IC50=530 nM). KH-CB19 shows antiviral activity and inhibits influenza virus replication (IC50=13.6?μM).
体外研究:
KH-CB19 (10 μM; 1 h) shows CLK inhibition on SR protein phosphorylation in human microvascular endothelial cells.KH-CB19 (50?μM; 6 h) inhibits the disruption by CLK4 in A549?cells.