产品
编 号：F132825
分子式：C19H15Cl2F2NO7S
分子量：510.29
分子式：C19H15Cl2F2NO7S
分子量：510.29
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规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
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5mg
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10mg
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结构图
CAS No: 1353546-86-7
产品详情
生物活性：
Orismilast (LEO-32731) is an orally active and selective PDE4 inhibitor used for the research of inflammatory diseases. Orismilast demonstrates potent inhibition of PDE4B and PDE4D subtype splice variants.
体内研究：
Orismilast (10和30mg/kg) 显著降低耳部厚度和炎症标志物 (分别为p<0.0001)。Animal Model:Female BALB/cABomTac mice (sensitized to oxazolone on the right ear with a single application of 10 μl oxazolone (0.8% in acetone) on Day 7).
Dosage:10 and 30mg/kg.
Administration:Orally.
Result:Both the 10 mg/kg and 30mg/kg doses of oral orismilast resulted in a significant reduction in ear thickness over time (p<0.0001, respectively;) with no impact on bodyweight during the treatment period.
体外研究：
Orismilast 抑制肿瘤坏死因子α (TNFα) 以及外周血单个核细胞 (PBMC) 中T辅助 (Th) 1 (TNFα 和 IFNγ)、Th17 (IL-22和IL-23) 和Th2 (IL-4、IL-5和IL-13) 相关细胞因子的分泌。
Orismilast (LEO-32731) is an orally active and selective PDE4 inhibitor used for the research of inflammatory diseases. Orismilast demonstrates potent inhibition of PDE4B and PDE4D subtype splice variants.
体内研究：
Orismilast (10和30mg/kg) 显著降低耳部厚度和炎症标志物 (分别为p<0.0001)。Animal Model:Female BALB/cABomTac mice (sensitized to oxazolone on the right ear with a single application of 10 μl oxazolone (0.8% in acetone) on Day 7).
Dosage:10 and 30mg/kg.
Administration:Orally.
Result:Both the 10 mg/kg and 30mg/kg doses of oral orismilast resulted in a significant reduction in ear thickness over time (p<0.0001, respectively;) with no impact on bodyweight during the treatment period.
体外研究：
Orismilast 抑制肿瘤坏死因子α (TNFα) 以及外周血单个核细胞 (PBMC) 中T辅助 (Th) 1 (TNFα 和 IFNγ)、Th17 (IL-22和IL-23) 和Th2 (IL-4、IL-5和IL-13) 相关细胞因子的分泌。
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