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编 号：F131542
分子式：C21H37NO2
分子量：335.52
分子式：C21H37NO2
分子量：335.52
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CAS No: 1351056-65-9
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生物活性：
OSU-2S is a potent PKCδ activator. OSU-2S inhibits cell proliferation and migration. OSU-2S decreases the expression of p-ERK1/2, increases the expression of PKCδ (38 kDa) when combined with Sorafenib (HY-10201). OSU-2S induces Apoptosis. OSU-2S slao is a non-immunosuppressive analogue of FTY720. OSU-2S shows anticancer activity.
体内研究：
OSU-2S (5, 10 mg/kg; i.p.; once daily for 42 days) 抑制小鼠的肿瘤生长。Animal Model:CD2F1 mice (Hep3B tumor xenograft models)
Dosage:5, 10 mg/kg
Administration:I.p.; once daily for 42 days
Result:Exhibited a higher tumor-suppressive potency, achieving 80% reduction in bioluminescence at the end of treatment.
体外研究：
OSU-2S (1.25, 2.5 μM; 48 h) 与 Sorafenib (HY-10201) (2.5, 5 μM) 联用时，降低 p-ERK1/2 的表达，增加 PKCδ (38 kDa) 的表达。OSU-2S/Sorafenib (1.25, 2.5 μM; 8 h) 组合抑制细胞增殖和迁移。OSU-2S (0, 1, 2.5, 5 μM; 0-24 h) 以剂量和时间依赖性方式降低 Hep3B 细胞中 PARP 的表达。OSU-2S (5 μM; 12, 24 h) 诱导 Hep3B 细胞凋亡。OSU-2S (0-10 μM; 1 h) 以剂量依赖性方式刺激 Hep3B、Huh7、PLC-5 细胞中 ROS 的产生。
OSU-2S is a potent PKCδ activator. OSU-2S inhibits cell proliferation and migration. OSU-2S decreases the expression of p-ERK1/2, increases the expression of PKCδ (38 kDa) when combined with Sorafenib (HY-10201). OSU-2S induces Apoptosis. OSU-2S slao is a non-immunosuppressive analogue of FTY720. OSU-2S shows anticancer activity.
体内研究：
OSU-2S (5, 10 mg/kg; i.p.; once daily for 42 days) 抑制小鼠的肿瘤生长。Animal Model:CD2F1 mice (Hep3B tumor xenograft models)
Dosage:5, 10 mg/kg
Administration:I.p.; once daily for 42 days
Result:Exhibited a higher tumor-suppressive potency, achieving 80% reduction in bioluminescence at the end of treatment.
体外研究：
OSU-2S (1.25, 2.5 μM; 48 h) 与 Sorafenib (HY-10201) (2.5, 5 μM) 联用时，降低 p-ERK1/2 的表达，增加 PKCδ (38 kDa) 的表达。OSU-2S/Sorafenib (1.25, 2.5 μM; 8 h) 组合抑制细胞增殖和迁移。OSU-2S (0, 1, 2.5, 5 μM; 0-24 h) 以剂量和时间依赖性方式降低 Hep3B 细胞中 PARP 的表达。OSU-2S (5 μM; 12, 24 h) 诱导 Hep3B 细胞凋亡。OSU-2S (0-10 μM; 1 h) 以剂量依赖性方式刺激 Hep3B、Huh7、PLC-5 细胞中 ROS 的产生。
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