产品
编 号：F129919
分子式：C29H29N5O3S
分子量：527.64
分子式：C29H29N5O3S
分子量：527.64
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CAS No: 1346669-54-2
产品详情
生物活性：
G-744 is a highly potent, selective and orally active Btk inhibitor with an IC50 of 2 nM. G-744 is metabolically stable, well tolerated and efficacious to treat arthritis.
体内研究：
G-744 (6.25/12.25/25 mg/kg, p.o., b.i.d., daily) protects Lewis rats from collagen-induced arthritis dose-dependently.Animal Model:Female Lewis rat based CIA models.
Dosage:6.25, 12.25, 25 mg/kg.
Administration:Orally, b.i.d., daily for 17 days.
Result:All three doses resulted in a significant dose-dependent inhibition of ankle thickness between day 10 and day 17 (onset of increase in ankle diameter on day 9).
G-744 is a highly potent, selective and orally active Btk inhibitor with an IC50 of 2 nM. G-744 is metabolically stable, well tolerated and efficacious to treat arthritis.
体内研究：
G-744 (6.25/12.25/25 mg/kg, p.o., b.i.d., daily) protects Lewis rats from collagen-induced arthritis dose-dependently.Animal Model:Female Lewis rat based CIA models.
Dosage:6.25, 12.25, 25 mg/kg.
Administration:Orally, b.i.d., daily for 17 days.
Result:All three doses resulted in a significant dose-dependent inhibition of ankle thickness between day 10 and day 17 (onset of increase in ankle diameter on day 9).
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