产品
编 号：F001855
分子式：C17H14N6O4
分子量：366.33
分子式：C17H14N6O4
分子量：366.33
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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5mg
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10mg
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50mg
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100mg
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结构图
CAS No: 1002789-86-7
产品详情
生物活性：
TZ9 is a selective Rad6 inhibitor. TZ9 inhibits Rad6B-induced histone H2A ubiquitination, downregulates intracellular β-catenin, induces G2-M arrest and apoptosis, and inhibits the proliferation and migration of metastatic human breast cancer cells.
体外研究：
TZ9 (Rad6B SMI #9) (0.5-100 μM; 72 h) inhibits MDA-MB-231 cell proliferation and migration.TZ9 (0.1-5 μM; 24-72 h) delays cell-cycle progression in MDA-MB-231 cells.TZ9 (5 μM; 8-48 h) induces apoptosis in MDA-MB-231 cells.TZ9 (0.5, 1, 2.5, 5 μM; 24 h) inhibits H2A ubiquitination and downregulates levels of PCNA and β-catenin protein in MDA-MB-231 cells.
TZ9 is a selective Rad6 inhibitor. TZ9 inhibits Rad6B-induced histone H2A ubiquitination, downregulates intracellular β-catenin, induces G2-M arrest and apoptosis, and inhibits the proliferation and migration of metastatic human breast cancer cells.
体外研究：
TZ9 (Rad6B SMI #9) (0.5-100 μM; 72 h) inhibits MDA-MB-231 cell proliferation and migration.TZ9 (0.1-5 μM; 24-72 h) delays cell-cycle progression in MDA-MB-231 cells.TZ9 (5 μM; 8-48 h) induces apoptosis in MDA-MB-231 cells.TZ9 (0.5, 1, 2.5, 5 μM; 24 h) inhibits H2A ubiquitination and downregulates levels of PCNA and β-catenin protein in MDA-MB-231 cells.
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