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编 号：F128829
分子式：C10H11N2NaO4
分子量：246.2
分子式：C10H11N2NaO4
分子量：246.2
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CAS No: 134624-73-0
产品详情
生物活性：
Stavudine (d4T) sodium is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Stavudine sodium has activity against HIV-1 and HIV-2. Stavudine sodium also inhibits the replication of mitochondrial DNA (mtDNA). Stavudine sodium reduces NLRP3 inflammasome activation and modulates Amyloid-β autophagy. Stavudine sodium induces apoptosis.
体内研究：
Stavudine (d4T) sodium (500 mg/kg, daily liquid, 2 weeks) can rapidly induce fat depletion and mild liver damage at high dose in male RjOrl Swiss mice.Animal Model:Male RjOrl Swiss mice weighing 0.028-0.03 kg
Dosage:500 mg/kg
Administration:Daily liquid; 2 weeks
Result:Reduced fat weight gain by 58%, 5.7 g in the control group and 4.9 g in the d4T treated group.Significantly elevated plasma ALT and LDH levels.Reduced plasma acetoacetic acid and beta-hydroxybutyric acid levels.Reduced liver and muscle mtDNA levels at high dose concentration of 500 mg/kg.
体外研究：
Stavudine (d4T) sodium (50 μM) significantly reduces the expression of the NLRP3 inflammasome gene, IL-18 production and Aβ 42-stimulated cellular production of IL-1β in THP-1 derived macrophages.Stavudine (d4T) sodium (50 μM) inhibits the assembly of the NLRP3 inflammasome complex and down-regulates the phagocytosis of Aβ 42 by macrophages.Stavudine (d4T) sodium (10 μM, 7 or 14 days) significantly induced CEM cells apoptosis, especially after 14 days, and increases hydrogen peroxide levels.
Stavudine (d4T) sodium is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Stavudine sodium has activity against HIV-1 and HIV-2. Stavudine sodium also inhibits the replication of mitochondrial DNA (mtDNA). Stavudine sodium reduces NLRP3 inflammasome activation and modulates Amyloid-β autophagy. Stavudine sodium induces apoptosis.
体内研究：
Stavudine (d4T) sodium (500 mg/kg, daily liquid, 2 weeks) can rapidly induce fat depletion and mild liver damage at high dose in male RjOrl Swiss mice.Animal Model:Male RjOrl Swiss mice weighing 0.028-0.03 kg
Dosage:500 mg/kg
Administration:Daily liquid; 2 weeks
Result:Reduced fat weight gain by 58%, 5.7 g in the control group and 4.9 g in the d4T treated group.Significantly elevated plasma ALT and LDH levels.Reduced plasma acetoacetic acid and beta-hydroxybutyric acid levels.Reduced liver and muscle mtDNA levels at high dose concentration of 500 mg/kg.
体外研究：
Stavudine (d4T) sodium (50 μM) significantly reduces the expression of the NLRP3 inflammasome gene, IL-18 production and Aβ 42-stimulated cellular production of IL-1β in THP-1 derived macrophages.Stavudine (d4T) sodium (50 μM) inhibits the assembly of the NLRP3 inflammasome complex and down-regulates the phagocytosis of Aβ 42 by macrophages.Stavudine (d4T) sodium (10 μM, 7 or 14 days) significantly induced CEM cells apoptosis, especially after 14 days, and increases hydrogen peroxide levels.
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