产品
编 号：F128796
分子式：C23H22ClN3O2
分子量：407.89
分子式：C23H22ClN3O2
分子量：407.89
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
2mg
询价
询价
5mg
询价
询价
10mg
询价
询价
50mg
询价
询价
100mg
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询价
结构图
CAS No: 1346133-08-1
产品详情
生物活性：
LY2795050 is a short-acting selective κ(kappa)-opioid receptor (KOR) antagonist. LY2795050 has high affinity for the KOR with Ki value of 0.72 nM. LY2795050 can be used for the research of central nervous system dysfunction.
体内研究：
LY2795050 (i.p., 0.032-0.1mg/kg, 30 min) prevents dose-dependent grooming deficits produced by U50,488 in male and female mice.LY2795050 (i.p., 0.032-0.1mg/kg, 0-150 min) has sexual dimorphism in some behavioral effects.Animal Model:C57BL/6J mice(gonadally intact, adult, male and female)
Dosage:0.032-0.1 mg/kg
Administration:i.p., 0.032-0.1mg/kg, 30 min
Result:Could dose-dependently prevent the self-grooming deficits caused by U50,488 with a 30-min pre-treatment.Not effected in blocking the effects of U50,488 with smaller dose (0.032mg/kg) in either males or females.Decreased immobility in the FST in males at a dose of 0.1mg/kg, but not in females, up to a dose of 0.32mg/kg.Prevented and also reversed (at 0.32mg/kg) the locomotor-depressant effects of U50,488 (10mg/kg), in males and females.
体外研究：
LY2795050 displays high affinity with a Ki value of 0.72 nM for the KOR and has antagonist activity with a Kb value of 0.63 nM.
LY2795050 is a short-acting selective κ(kappa)-opioid receptor (KOR) antagonist. LY2795050 has high affinity for the KOR with Ki value of 0.72 nM. LY2795050 can be used for the research of central nervous system dysfunction.
体内研究：
LY2795050 (i.p., 0.032-0.1mg/kg, 30 min) prevents dose-dependent grooming deficits produced by U50,488 in male and female mice.LY2795050 (i.p., 0.032-0.1mg/kg, 0-150 min) has sexual dimorphism in some behavioral effects.Animal Model:C57BL/6J mice(gonadally intact, adult, male and female)
Dosage:0.032-0.1 mg/kg
Administration:i.p., 0.032-0.1mg/kg, 30 min
Result:Could dose-dependently prevent the self-grooming deficits caused by U50,488 with a 30-min pre-treatment.Not effected in blocking the effects of U50,488 with smaller dose (0.032mg/kg) in either males or females.Decreased immobility in the FST in males at a dose of 0.1mg/kg, but not in females, up to a dose of 0.32mg/kg.Prevented and also reversed (at 0.32mg/kg) the locomotor-depressant effects of U50,488 (10mg/kg), in males and females.
体外研究：
LY2795050 displays high affinity with a Ki value of 0.72 nM for the KOR and has antagonist activity with a Kb value of 0.63 nM.
产品资料
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