产品
编 号：F128504
分子式：C33H34Ca0.5FN2O5
分子量：577.67
分子式：C33H34Ca0.5FN2O5
分子量：577.67
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
190
In-stock
10mg
304
In-stock
50mg
560
In-stock
100mg
836
In-stock
200mg
1338
In-stock
500mg
2800
In-stock
结构图
CAS No: 134523-03-8
产品详情
生物活性：
Atorvastatin hemicalcium salt (CI-981) is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin hemicalcium salt inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively.
体内研究：
Atorvastatin (20-30 mg/kg; oral gavage; once a day; for 28 days; ApoE?/? mice) treatment significantly reduces endoplasmic reticulum (ER) stress signaling proteins, the number of apoptotic cells, and the activation of Caspase12 and Bax in the Ang II-induced ApoE-/- mice. Proinflammatory cytokines such as IL-6, IL-8, IL-1β are all remarkably inhibited after Atorvastatin treatment.Animal Model:Forty 8-week-old ApoE?/? mice induced with angiotensin II (Ang II)
Dosage:20 mg/kg, 30 mg/kg
Administration:Oral gavage; once a day; for 28 days
Result:Significantly reduced ER stress signaling proteins, the number of apoptotic cells, and the activation of Caspase12 and Bax in the Ang II-induced ApoE?/? mice. Proinflammatory cytokines such as IL-6, IL-8, IL-1β were all remarkably inhibited
体外研究：
Atorvastatin treatment decreases apoptosis of myocardial cells by down-regulating GRP78, caspase-12 and CHOP expression in myocardial cells after myocardial infarction, and the endoplasmic reticulum (ER) stress is activated in response to heart failure and angiotensin II (Ang II) stimulation.
Atorvastatin hemicalcium salt (CI-981) is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin hemicalcium salt inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively.
体内研究：
Atorvastatin (20-30 mg/kg; oral gavage; once a day; for 28 days; ApoE?/? mice) treatment significantly reduces endoplasmic reticulum (ER) stress signaling proteins, the number of apoptotic cells, and the activation of Caspase12 and Bax in the Ang II-induced ApoE-/- mice. Proinflammatory cytokines such as IL-6, IL-8, IL-1β are all remarkably inhibited after Atorvastatin treatment.Animal Model:Forty 8-week-old ApoE?/? mice induced with angiotensin II (Ang II)
Dosage:20 mg/kg, 30 mg/kg
Administration:Oral gavage; once a day; for 28 days
Result:Significantly reduced ER stress signaling proteins, the number of apoptotic cells, and the activation of Caspase12 and Bax in the Ang II-induced ApoE?/? mice. Proinflammatory cytokines such as IL-6, IL-8, IL-1β were all remarkably inhibited
体外研究：
Atorvastatin treatment decreases apoptosis of myocardial cells by down-regulating GRP78, caspase-12 and CHOP expression in myocardial cells after myocardial infarction, and the endoplasmic reticulum (ER) stress is activated in response to heart failure and angiotensin II (Ang II) stimulation.
产品资料
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