产品
编 号：F128502
分子式：C33H35FN2O5
分子量：558.64
分子式：C33H35FN2O5
分子量：558.64
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
190
In-stock
10mg
304
In-stock
50mg
560
In-stock
100mg
836
In-stock
结构图
CAS No: 134523-00-5
产品详情
生物活性：
Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively.
体内研究：
Atorvastatin (20-30 mg/kg; oral gavage; once a day; for 28 days; ApoE?/? mice) treatment significantly reduces endoplasmic reticulum (ER) stress signaling proteins, the number of apoptotic cells, and the activation of Caspase12 and Bax in the Ang II-induced ApoE-/- mice. Proinflammatory cytokines such as IL-6, IL-8, IL-1β are all remarkably inhibited after Atorvastatin treatment.Animal Model:Forty 8-week-old ApoE?/? mice induced with angiotensin II (Ang II)
Dosage:20 mg/kg, 30 mg/kg
Administration:Oral gavage; once a day; for 28 days
Result:Significantly reduced ER stress signaling proteins, the number of apoptotic cells, and the activation of Caspase12 and Bax in the Ang II-induced ApoE?/? mice. Proinflammatory cytokines such as IL-6, IL-8, IL-1β were all remarkably inhibited.
体外研究：
Atorvastatin treatment decreases apoptosis of myocardial cells by down-regulating GRP78, caspase-12 and CHOP expression in myocardial cells after myocardial infarction, and the endoplasmic reticulum (ER) stress is activated in response to heart failure and angiotensin II (Ang II) stimulation.
Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively.
体内研究：
Atorvastatin (20-30 mg/kg; oral gavage; once a day; for 28 days; ApoE?/? mice) treatment significantly reduces endoplasmic reticulum (ER) stress signaling proteins, the number of apoptotic cells, and the activation of Caspase12 and Bax in the Ang II-induced ApoE-/- mice. Proinflammatory cytokines such as IL-6, IL-8, IL-1β are all remarkably inhibited after Atorvastatin treatment.Animal Model:Forty 8-week-old ApoE?/? mice induced with angiotensin II (Ang II)
Dosage:20 mg/kg, 30 mg/kg
Administration:Oral gavage; once a day; for 28 days
Result:Significantly reduced ER stress signaling proteins, the number of apoptotic cells, and the activation of Caspase12 and Bax in the Ang II-induced ApoE?/? mice. Proinflammatory cytokines such as IL-6, IL-8, IL-1β were all remarkably inhibited.
体外研究：
Atorvastatin treatment decreases apoptosis of myocardial cells by down-regulating GRP78, caspase-12 and CHOP expression in myocardial cells after myocardial infarction, and the endoplasmic reticulum (ER) stress is activated in response to heart failure and angiotensin II (Ang II) stimulation.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备