产品
编 号：F128081
分子式：C10H12N2O3
分子量：208.21
分子式：C10H12N2O3
分子量：208.21
产品类型
规格
价格
是否有货
25mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 13441-51-5
产品详情
生物活性：
D-kynurenine, a metabolite of D-tryptophan, can serve as the bioprecursor of kynurenic acid (KYNA) and 3-hydroxykynurenine. D-Kynurenine is an agonist for G protein-coupled receptor, GPR109B. D-Kynurenine is a substrate in a fluorometric assay of D-amino acid oxidase. D-kynurenine promotes epithelial-to-mesenchymal transition via activating aryl hydrocarbon receptor (AHR).
体外研究：
D-kynurenine (10, 40, 60, and 100 μM) positively regulates the metastasis of 95D cells, a lung cancer cell line, which is reduced upon siRNAAhr treatment. Significant enhancement VIM expression was detected in the presence of D-kynurenine (10 and 40 μM). 10 μM D-kynurenine markedly attenuates E-cadherin level. 10 μM D-kynurenine-mediated changes of VIM and E-cadherin are substantially attenuated on siRNAAhr treatment as well. The evidences-10/40 μM D-kynurenine-induced up-regulation of CYP1A1, 10 μM D-kynurenine-induced increase of nuclear transfer of Ahr, and 10/40/60/100 μM D-kynurenine-induced enhancement of DER-luciferase activity-indicated that D-kynurenine Is capable of activating Ahr in fact.
D-kynurenine, a metabolite of D-tryptophan, can serve as the bioprecursor of kynurenic acid (KYNA) and 3-hydroxykynurenine. D-Kynurenine is an agonist for G protein-coupled receptor, GPR109B. D-Kynurenine is a substrate in a fluorometric assay of D-amino acid oxidase. D-kynurenine promotes epithelial-to-mesenchymal transition via activating aryl hydrocarbon receptor (AHR).
体外研究：
D-kynurenine (10, 40, 60, and 100 μM) positively regulates the metastasis of 95D cells, a lung cancer cell line, which is reduced upon siRNAAhr treatment. Significant enhancement VIM expression was detected in the presence of D-kynurenine (10 and 40 μM). 10 μM D-kynurenine markedly attenuates E-cadherin level. 10 μM D-kynurenine-mediated changes of VIM and E-cadherin are substantially attenuated on siRNAAhr treatment as well. The evidences-10/40 μM D-kynurenine-induced up-regulation of CYP1A1, 10 μM D-kynurenine-induced increase of nuclear transfer of Ahr, and 10/40/60/100 μM D-kynurenine-induced enhancement of DER-luciferase activity-indicated that D-kynurenine Is capable of activating Ahr in fact.
产品资料
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