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编 号：F127701
分子式：C27H35N5O4S
分子量：525.66
分子式：C27H35N5O4S
分子量：525.66
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CAS No: 134362-79-1
产品详情
生物活性：
Ro 0437626 is a selective purinergic (P2X1) receptor antagonist (IC50 = 3 μM), but shows low affinity for P2X2, P2X3 and P2X2/3 receptors (IC50 > 100 μM).
体内研究：
Ro 0437626 (1 and 10 μmol/kg; i.v.) causes a reduction in postinfusion isovolumetric contractions.Animal Model:Female rat (urethane-anaesthetized)
Dosage:1 and 10 μmol/kg
Administration:I.v.
Result:Caused a reduction in postinfusion isovolumetric contractions.
体外研究：
Ro 0437626 reduces PMA-evoked Ca2+entry with 6.8 ± 4.7% of control.
Ro 0437626 is a selective purinergic (P2X1) receptor antagonist (IC50 = 3 μM), but shows low affinity for P2X2, P2X3 and P2X2/3 receptors (IC50 > 100 μM).
体内研究：
Ro 0437626 (1 and 10 μmol/kg; i.v.) causes a reduction in postinfusion isovolumetric contractions.Animal Model:Female rat (urethane-anaesthetized)
Dosage:1 and 10 μmol/kg
Administration:I.v.
Result:Caused a reduction in postinfusion isovolumetric contractions.
体外研究：
Ro 0437626 reduces PMA-evoked Ca2+entry with 6.8 ± 4.7% of control.
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