产品
编 号：F127370
分子式：C14H11NO5
分子量：273.24
分子式：C14H11NO5
分子量：273.24
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
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10mg
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50mg
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100mg
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结构图
CAS No: 134308-13-7
产品详情
生物活性：
Tolcapone (Ro 40-7592) is a selective, orally active and powerful mixed (peripheral and central) COMT inhibitor with an IC50 of 773?nM in the liver. Tolcapone is also a potent inhibitor of α-syn and Aβ42 oligomerization and fibrillogenesis. Tolcapone induces oxidative stress leading to apoptosis and inhibition of tumor growth in neuroblastoma.
体内研究：
Tolcapone (125 mg/kg; orally) inhibits tumor growth and prolongs survival in vivo. There are no adverse events or differences in weight or behavior noted in the mice.Animal Model:4-week-old female nude mice (nu/nu) bearing SMS‐KCNR xenograft models
Dosage:125 mg/kg
Administration:Treated orally every 24 h for 35 days
Result:Decreased tumor volume compared to control.Resulted in a smaller average tumor of 490±310 mm3 compared to control tumors of 1100±450 mm3.
体外研究：
Tolcapone is cytotoxic to neuroblastoma (NB) cells with IC50 values ranging from 32.27 μM for SMS-KCNR cells to 219.8 μM for MGT9-102-08 primary cells.?Tolcapone (25, 50,75, 100 μM) treatment activates downstream apoptotic events in NB cells. Tolcapone induces caspase-mediated apoptosis in neuroblastoma.
Tolcapone (Ro 40-7592) is a selective, orally active and powerful mixed (peripheral and central) COMT inhibitor with an IC50 of 773?nM in the liver. Tolcapone is also a potent inhibitor of α-syn and Aβ42 oligomerization and fibrillogenesis. Tolcapone induces oxidative stress leading to apoptosis and inhibition of tumor growth in neuroblastoma.
体内研究：
Tolcapone (125 mg/kg; orally) inhibits tumor growth and prolongs survival in vivo. There are no adverse events or differences in weight or behavior noted in the mice.Animal Model:4-week-old female nude mice (nu/nu) bearing SMS‐KCNR xenograft models
Dosage:125 mg/kg
Administration:Treated orally every 24 h for 35 days
Result:Decreased tumor volume compared to control.Resulted in a smaller average tumor of 490±310 mm3 compared to control tumors of 1100±450 mm3.
体外研究：
Tolcapone is cytotoxic to neuroblastoma (NB) cells with IC50 values ranging from 32.27 μM for SMS-KCNR cells to 219.8 μM for MGT9-102-08 primary cells.?Tolcapone (25, 50,75, 100 μM) treatment activates downstream apoptotic events in NB cells. Tolcapone induces caspase-mediated apoptosis in neuroblastoma.
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