产品
编 号：F127291
分子式：C19H26ClN4O2-
分子量：377.89
分子式：C19H26ClN4O2-
分子量：377.89
产品类型
规格
价格
是否有货
1mg
询价
询价
结构图
CAS No: 134296-40-5
产品详情
生物活性：
BIMU 8 is a potent and selective 5-HT4 agonist with EC50s of 18 nM, 77 nM, and 540 nM for wild type 5HT4 receptor, T3.36A, and W6.48A mutant 5-HT4 receptors.
体内研究：
In mice and rats, BIMU 8 (20-30 mg/kg s.c. and 60 mg/kg p.o. in mice; 20 mg/kg i.p. in rats), produces significant antinociception.Intracerebroventricular injection in mice of BIMU 8 (10 μg/mouse), doses which are largely ineffective by parenteral routes, induces an antinociception whose intensity equaled that obtainable s.c., i.p. or p.o.
体外研究：
In myenteric neurons of guinea pig ileum, BIMU 8 (0.003-0.1 μM) increases excitatory postsynaptic potentials (EPSPs) mplitude but does not change the membrane potential of any neuron.
BIMU 8 is a potent and selective 5-HT4 agonist with EC50s of 18 nM, 77 nM, and 540 nM for wild type 5HT4 receptor, T3.36A, and W6.48A mutant 5-HT4 receptors.
体内研究：
In mice and rats, BIMU 8 (20-30 mg/kg s.c. and 60 mg/kg p.o. in mice; 20 mg/kg i.p. in rats), produces significant antinociception.Intracerebroventricular injection in mice of BIMU 8 (10 μg/mouse), doses which are largely ineffective by parenteral routes, induces an antinociception whose intensity equaled that obtainable s.c., i.p. or p.o.
体外研究：
In myenteric neurons of guinea pig ileum, BIMU 8 (0.003-0.1 μM) increases excitatory postsynaptic potentials (EPSPs) mplitude but does not change the membrane potential of any neuron.
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