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编 号：F125766
分子式：C15H9N5
分子量：259.27
分子式：C15H9N5
分子量：259.27
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CAS No: 134036-53-6
产品详情
生物活性：
AG 370, an indole tyrphostin, is a potent PDGF-induced mitogenesis inhibotor (IC50 of 20 μM). AG 370 displays weak inhibition of the EGF receptor.
体外研究：
AG 370 blocks mitogenesis induced by epidermal growth factor (IC50 of 50 μM) and human serum (IC50 of 50 μM).In Digitonin-permeabilized fibroblasts as well as in intact fibroblasts, tyrphostin AG 370 inhibits PDGF receptor autophosphorylation and the tyrosine phosphorylation of intracellular protein substrates (pp120, pp85, and pp75) which coprecipitate with the PDGF receptor.
AG 370, an indole tyrphostin, is a potent PDGF-induced mitogenesis inhibotor (IC50 of 20 μM). AG 370 displays weak inhibition of the EGF receptor.
体外研究：
AG 370 blocks mitogenesis induced by epidermal growth factor (IC50 of 50 μM) and human serum (IC50 of 50 μM).In Digitonin-permeabilized fibroblasts as well as in intact fibroblasts, tyrphostin AG 370 inhibits PDGF receptor autophosphorylation and the tyrosine phosphorylation of intracellular protein substrates (pp120, pp85, and pp75) which coprecipitate with the PDGF receptor.
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