生物活性: Nattokinase, Natto fermentation is a potent fibrinolytic enzyme. Nattokinase can break down blood clots by directly hydrolyzing fibrin and plasmin substrate. Nattokinase can be used for the research of cardiovascular diseases.
体内研究: Nattokinase (150-250 mg/kg;每天口服两次,持续 2 天) 表现出纤维蛋白溶解活性并在体内溶解血块。Animal Model:Sprague-Dawley (SD) rats (180-220 g) are injected κ-Carrageenan
Dosage:150, 250 mg/kg
Administration:Oral gavage twice daily for 2 days
Result:Increased the plasma concentration of fibrin/fibrinogen degradation products (FDPs) and D-Dimer in a dose-dependent manner.Decreased the fraction of the vessel cross section occupied by thrombosis.