产品
编 号：F124619
分子式：C23H25ClN2O2S
分子量：428.97
分子式：C23H25ClN2O2S
分子量：428.97
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
2mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 1338545-07-5
产品详情
生物活性：
OTS964 hydrochloride is an orally active, high affinity and selective TOPK (T-lymphokine-activated killer cell-originated protein kinase) inhibitor with an IC50 of 28 nM. OTS964 hydrochloride is also a potent inhibitor of the cyclin-dependent kinase CDK11, which binds to CDK11B with a Kd of 40 nM.
体内研究：
OTS964 hydrochloride (intravenously; 40 mg/kg on days 1, 4, 8, 11, 15, and 18) makes tumors shrinking even after the treatment and finally revealing complete regression. OTS964 hydrochloride (oral administration; 50 or 100 mg/kg/day for 2 weeks) ultimately achieves complete tumor regression.Animal Model:Nude mice bearing LU-99 lung cancer cells
Dosage:40 mg/kg
Administration:Intravenously; on days 1, 4, 8, 11, 15, and 18
Result:The tumors continued shrinking even after the treatment and finally revealed complete regression.
Animal Model:Nude mice bearing LU-99 lung cancer cells
Dosage:50 or 100 mg/kg
Administration:Oral administration; once every day for 2 weeks
Result:Achieved complete tumor regression.
体外研究：
OTS964 hydrochloride (10 nM; 48 hours) suppresses cancer cell proliferation. OTS964 hydrochloride (10 nM; 48 hours) increases cancer cell death. OTS964 (0.1-2 μM; 24 and 48 hours) increases the expression of LC3-II and decreases the expression of P62, both in a dose-dependent manner.
OTS964 hydrochloride is an orally active, high affinity and selective TOPK (T-lymphokine-activated killer cell-originated protein kinase) inhibitor with an IC50 of 28 nM. OTS964 hydrochloride is also a potent inhibitor of the cyclin-dependent kinase CDK11, which binds to CDK11B with a Kd of 40 nM.
体内研究：
OTS964 hydrochloride (intravenously; 40 mg/kg on days 1, 4, 8, 11, 15, and 18) makes tumors shrinking even after the treatment and finally revealing complete regression. OTS964 hydrochloride (oral administration; 50 or 100 mg/kg/day for 2 weeks) ultimately achieves complete tumor regression.Animal Model:Nude mice bearing LU-99 lung cancer cells
Dosage:40 mg/kg
Administration:Intravenously; on days 1, 4, 8, 11, 15, and 18
Result:The tumors continued shrinking even after the treatment and finally revealed complete regression.
Animal Model:Nude mice bearing LU-99 lung cancer cells
Dosage:50 or 100 mg/kg
Administration:Oral administration; once every day for 2 weeks
Result:Achieved complete tumor regression.
体外研究：
OTS964 hydrochloride (10 nM; 48 hours) suppresses cancer cell proliferation. OTS964 hydrochloride (10 nM; 48 hours) increases cancer cell death. OTS964 (0.1-2 μM; 24 and 48 hours) increases the expression of LC3-II and decreases the expression of P62, both in a dose-dependent manner.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备