产品
编 号：F124612
分子式：C21H20N2O2S
分子量：364.46
分子式：C21H20N2O2S
分子量：364.46
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
2mg
880
In-stock
5mg
1600
In-stock
10mg
2520
In-stock
25mg
4280
In-stock
50mg
6000
In-stock
结构图
CAS No: 1338540-63-8
产品详情
生物活性：
OTS514 is a highly potent TOPK inhibitor with an IC50 of 2.6 nM. OTS514 strongly suppresses the growth of TOPK-positive cancer cells. OTS514 induces cell cycle arrest and apoptosis.
体内研究：
OTS514 (1-5 mg/kg; once a day for 2 weeks; intravenous administration) induces tumor regression in a xenograft model of A549 cells (TOPK-positive lung cancer cells).Animal Model:Female BALB/cSLC-nu/nu mice bearing a xenograft model of A549 cells
Dosage:1, 2.5, and 5 mg/kg
Administration:Intravenously treated; once every day for 2 weeks
Result:Resulted in tumor growth inhibition (TGI) of 5.7, 43.3, and 65.3% on day 15, respectively, without any body weight loss.
体外研究：
OTS514 (1.5625-100 nM) induces cell cycle arrest and apoptosis at nanomolar concentrations in a series of human myeloma cell lines (HMCL) and prevents outgrowth of a putative CD138+ stem cell population from multiple myeloma (MM) patient-derived peripheral blood mononuclear cells.
OTS514 is a highly potent TOPK inhibitor with an IC50 of 2.6 nM. OTS514 strongly suppresses the growth of TOPK-positive cancer cells. OTS514 induces cell cycle arrest and apoptosis.
体内研究：
OTS514 (1-5 mg/kg; once a day for 2 weeks; intravenous administration) induces tumor regression in a xenograft model of A549 cells (TOPK-positive lung cancer cells).Animal Model:Female BALB/cSLC-nu/nu mice bearing a xenograft model of A549 cells
Dosage:1, 2.5, and 5 mg/kg
Administration:Intravenously treated; once every day for 2 weeks
Result:Resulted in tumor growth inhibition (TGI) of 5.7, 43.3, and 65.3% on day 15, respectively, without any body weight loss.
体外研究：
OTS514 (1.5625-100 nM) induces cell cycle arrest and apoptosis at nanomolar concentrations in a series of human myeloma cell lines (HMCL) and prevents outgrowth of a putative CD138+ stem cell population from multiple myeloma (MM) patient-derived peripheral blood mononuclear cells.
产品资料
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