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编 号:F124294
分子式:C24H20F3N5O
分子量:451.44
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10mM*1mL in DMSO
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2mg
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5mg
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10mg
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50mg
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100mg
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生物活性:
GSK2606414 is a cell-permeable and orally available protein kinase R-like endoplasmic reticulum (ER) kinase (PERK) inhibitor with an IC50 of 0.4 nM.

体内研究:
GSK2606414 (50 and 150 mg/kg, p.o.) inhibits the growth of a human tumor xenograft in mice.

体外研究:
GSK2606414 inhibits PERK activation in cells.
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