产品
编 号:F124294
分子式:C24H20F3N5O
分子量:451.44
产品类型
结构图
CAS No: 1337531-36-8
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产品详情
生物活性:
GSK2606414 is a cell-permeable and orally available protein kinase R-like endoplasmic reticulum (ER) kinase (PERK) inhibitor with an IC50 of 0.4 nM.
体内研究:
GSK2606414 (50 and 150 mg/kg, p.o.) inhibits the growth of a human tumor xenograft in mice.
体外研究:
GSK2606414 inhibits PERK activation in cells.