产品
编 号：F124023
分子式：C11H14O3
分子量：194.23
分子式：C11H14O3
分子量：194.23
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CAS No: 133613-71-5
产品详情
生物活性：
Galiellalactone is a is a small non-toxic and non-mutagenic fungal metabolite, a selective inhibitor of STAT3 signaling, with an IC50 of 250-500 nM. Galiellalactone can be used to research castration-resistant prostate cancer.
体内研究：
Galiellalactone (1, 3?mg/kg; daily i.p. for 3 weeks) inhibits PCa tumor growth in vivo.Animal Model:Male nude NMR1 mice are injected PCa cell
Dosage:0, 1, 3?mg/kg
Administration:Daily i.p. injections for 3 weeks
Result:Reduced the tumor growth rate in DU145 xenografts by 41-42% and was well tolerated.
体外研究：
Galiellalactone (2.5-25 μM; 24-72 hour) induces apoptosis of prostate cancer (PCa) cell lines expressingp-Stat3.Galiellalactone (2.5-25 μM; 24-72 hour) decreases viability of DU145 cells.Galiellalactone (10 μM) inhibits STAT3 signaling activity as assessed by luciferase reporter gene assay in IL-6-stimulated LNCaP cells.Galiellalactone (10-100 μM; 1 hour) binds directly to STAT3 in DU145 cells .Galiellalactone (5-50 μM; 1 hour) interferes with STAT3 DNA binding without inhibiting phosphorylation in DU145 cells .
Galiellalactone is a is a small non-toxic and non-mutagenic fungal metabolite, a selective inhibitor of STAT3 signaling, with an IC50 of 250-500 nM. Galiellalactone can be used to research castration-resistant prostate cancer.
体内研究：
Galiellalactone (1, 3?mg/kg; daily i.p. for 3 weeks) inhibits PCa tumor growth in vivo.Animal Model:Male nude NMR1 mice are injected PCa cell
Dosage:0, 1, 3?mg/kg
Administration:Daily i.p. injections for 3 weeks
Result:Reduced the tumor growth rate in DU145 xenografts by 41-42% and was well tolerated.
体外研究：
Galiellalactone (2.5-25 μM; 24-72 hour) induces apoptosis of prostate cancer (PCa) cell lines expressingp-Stat3.Galiellalactone (2.5-25 μM; 24-72 hour) decreases viability of DU145 cells.Galiellalactone (10 μM) inhibits STAT3 signaling activity as assessed by luciferase reporter gene assay in IL-6-stimulated LNCaP cells.Galiellalactone (10-100 μM; 1 hour) binds directly to STAT3 in DU145 cells .Galiellalactone (5-50 μM; 1 hour) interferes with STAT3 DNA binding without inhibiting phosphorylation in DU145 cells .
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