产品
编 号：F123085
分子式：C26H41N3O5
分子量：475.62
分子式：C26H41N3O5
分子量：475.62
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 133407-83-7
产品详情
生物活性：
Z-LLNle-CHO (Z-Leu-Leu-Nle-CHO) is a γ-secretase inhibitor I. Z-LLNle-CHO induces caspase and ROS-dependent apoptosis by blocking the Akt-mediated pro-survival pathway. Z-LLNle-CHO can be used in cancer research, such as breast cancer and leukaemia.
体内研究：
Z-LLNle-CHO (5 mg/kg; s.c.; single daily for 12 days) inhibits engraftment of B-lymphoblasts in precursor-B ALL xenograft model.Animal Model:Female SCID/NOD mice (6-8-week-old; precursor-B ALL xenograft model).
Dosage:5 mg/kg
Administration:Subcutaneous injection; single daily for 12 days
Result:Delayed or prevented engraftment of B-lymphoblasts in 50% of the animals comprising the experimental group.
体外研究：
Z-LLNle-CHO (0-5 μM or 0-3 μM; 72 h) results in a dose-dependent decrease in cell viability/proliferation in six breast cancer cell lines.Z-LLNle-CHO shows proteasome inhibitory activity, which contributes to cytotoxicity to MCF-7 cells.Z-LLNle-CHO blocks Akt-mediated pro-survival pathways and induces caspase- and ROS-dependent cell apoptosis in Nalm6 and 697 cells.
Z-LLNle-CHO (Z-Leu-Leu-Nle-CHO) is a γ-secretase inhibitor I. Z-LLNle-CHO induces caspase and ROS-dependent apoptosis by blocking the Akt-mediated pro-survival pathway. Z-LLNle-CHO can be used in cancer research, such as breast cancer and leukaemia.
体内研究：
Z-LLNle-CHO (5 mg/kg; s.c.; single daily for 12 days) inhibits engraftment of B-lymphoblasts in precursor-B ALL xenograft model.Animal Model:Female SCID/NOD mice (6-8-week-old; precursor-B ALL xenograft model).
Dosage:5 mg/kg
Administration:Subcutaneous injection; single daily for 12 days
Result:Delayed or prevented engraftment of B-lymphoblasts in 50% of the animals comprising the experimental group.
体外研究：
Z-LLNle-CHO (0-5 μM or 0-3 μM; 72 h) results in a dose-dependent decrease in cell viability/proliferation in six breast cancer cell lines.Z-LLNle-CHO shows proteasome inhibitory activity, which contributes to cytotoxicity to MCF-7 cells.Z-LLNle-CHO blocks Akt-mediated pro-survival pathways and induces caspase- and ROS-dependent cell apoptosis in Nalm6 and 697 cells.
产品资料
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