产品
编 号：F121095
分子式：C69H116N26O15S2
分子量：1613.95
分子式：C69H116N26O15S2
分子量：1613.95
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 132956-87-7
产品详情
生物活性：
A 71915 is a highly potent and competitive natriuretic peptide receptor A (ANP, NPRA) antagonist (pKi= 9.18). A 71915 displaces [125I]ANP dose dependently, with a Ki of 0.65 nM. A71915( pA2= 9.48) against rat ANP-induced cGMP production in NB-OK-1 cells.
体内研究：
A 71915 (5 μl; i.m.; 25-30 g male CD-1 mice) affects BNP (1 nmol)- and GRP (0.1 nmol)-induced scratching.A 71915 (30 μg/ kg/ day) inhibits NS-398 on blood pressure decreased.Animal Model:Rat (Male Sprague-Dawley); weighing 150-180 g
Dosage:30 μg/kg/day; infused for 3 weeks
Administration:via a mini-osmotic pump
Result:The inhibitory effect of NS-398 on blood pressure was attenuated by the pretreatment with A 71915 (30 μg/kg/day).
体外研究：
A 71915 combines to Neuroblastoma NB-OK-1 cells, is used in the Cyclic GMP assay.A 71915 shifts the ANP dose-response curve of cyclic GMP production to the right.
A 71915 is a highly potent and competitive natriuretic peptide receptor A (ANP, NPRA) antagonist (pKi= 9.18). A 71915 displaces [125I]ANP dose dependently, with a Ki of 0.65 nM. A71915( pA2= 9.48) against rat ANP-induced cGMP production in NB-OK-1 cells.
体内研究：
A 71915 (5 μl; i.m.; 25-30 g male CD-1 mice) affects BNP (1 nmol)- and GRP (0.1 nmol)-induced scratching.A 71915 (30 μg/ kg/ day) inhibits NS-398 on blood pressure decreased.Animal Model:Rat (Male Sprague-Dawley); weighing 150-180 g
Dosage:30 μg/kg/day; infused for 3 weeks
Administration:via a mini-osmotic pump
Result:The inhibitory effect of NS-398 on blood pressure was attenuated by the pretreatment with A 71915 (30 μg/kg/day).
体外研究：
A 71915 combines to Neuroblastoma NB-OK-1 cells, is used in the Cyclic GMP assay.A 71915 shifts the ANP dose-response curve of cyclic GMP production to the right.
产品资料
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