产品
编 号：F120845
分子式：C10H11ClF3N3
分子量：265.66
分子式：C10H11ClF3N3
分子量：265.66
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
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10mg
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50mg
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100mg
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结构图
CAS No: 132834-56-1
产品详情
生物活性：
Org-12962 is a potent, selective and orally active 5-HT2C?receptor agonist with a pEC50?value of 7.01. Org-12962 also exhibits high effacy for the 5-HT2A?and 5-HT2B receptor with pEC50s of 6.38 and 6.28, respectively.Org-12962 displays antiaversive effects in a rat model of panic-like anxiety.
体内研究：
Org-12962 (intraperitoneal injection; 0.3-3.2 mg/kg) significantly increases the postinjection frequency thresholds for self-interruption (F3.71=11.40). Org-12962 is dissolved or microsuspended in 0.3% v/v Tween 80 in physiological saline (NaCl 0.9%).Animal Model:Male Wistar rats
Dosage:0.3 mg/kg, 1 mg/kg, 3.2 mg/kg
Administration:Intraperitoneal injection; 0.3-3.2 mg/kg
Result:Induced a dose-related antipanic-like effect.
Org-12962 is a potent, selective and orally active 5-HT2C?receptor agonist with a pEC50?value of 7.01. Org-12962 also exhibits high effacy for the 5-HT2A?and 5-HT2B receptor with pEC50s of 6.38 and 6.28, respectively.Org-12962 displays antiaversive effects in a rat model of panic-like anxiety.
体内研究：
Org-12962 (intraperitoneal injection; 0.3-3.2 mg/kg) significantly increases the postinjection frequency thresholds for self-interruption (F3.71=11.40). Org-12962 is dissolved or microsuspended in 0.3% v/v Tween 80 in physiological saline (NaCl 0.9%).Animal Model:Male Wistar rats
Dosage:0.3 mg/kg, 1 mg/kg, 3.2 mg/kg
Administration:Intraperitoneal injection; 0.3-3.2 mg/kg
Result:Induced a dose-related antipanic-like effect.
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