产品
编 号：F120819
分子式：C23H30FN3
分子量：367.5
分子式：C23H30FN3
分子量：367.5
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
260
In-stock
10mg
416
In-stock
25mg
688
In-stock
100mg
1680
In-stock
结构图
CAS No: 132810-10-7
产品详情
生物活性：
Blonanserin (AD-5423) is a potent?and orally active 5-HT2A?(Ki=0.812 nM) and?dopamine D2?receptor?(Ki =0.142?nM)?antagonist. Blonanserin is usually acts as an atypical antipsychotic?agent and can be used for the research of extrapyramidal symptoms, excessive?sedation, or?hypotension.
体内研究：
Blonanserin (oral gavage; 1 mg/kg; 14 days) significantly ameliorates the social deficit observed in PCP-administered mice and inhibits the decrease in the levels of Ser897-phosphorylation, but preatment with blonanserin does not affect the social behaviors in saline-administered mice.Animal Model:Mice received saline or phencyclidine once a day for 14 consecutive days
Dosage:1 mg/kg
Administration:Oral gavage; 1 mg/kg; 14 days
Result:Had an effect on the social deficit in mice that received repeated PCP administration.
体外研究：
Blonanserin exerts some blockade of?α1-adrenergic receptors?(Ki=26.7?nM) and also shows significant affinity for the?D3?receptor?(Ki=0.494 nM). Blonanserin possesses low affinity for the?sigma receptor?(IC50=286 nM), but lacks significant?affinity?for numerous other sites including the?5-HT1A,?5-HT3,?D1,?α2-adrenergic,?β-adrenergic,?H1, and?mACh receptors?and the?monoamine transporters.
Blonanserin (AD-5423) is a potent?and orally active 5-HT2A?(Ki=0.812 nM) and?dopamine D2?receptor?(Ki =0.142?nM)?antagonist. Blonanserin is usually acts as an atypical antipsychotic?agent and can be used for the research of extrapyramidal symptoms, excessive?sedation, or?hypotension.
体内研究：
Blonanserin (oral gavage; 1 mg/kg; 14 days) significantly ameliorates the social deficit observed in PCP-administered mice and inhibits the decrease in the levels of Ser897-phosphorylation, but preatment with blonanserin does not affect the social behaviors in saline-administered mice.Animal Model:Mice received saline or phencyclidine once a day for 14 consecutive days
Dosage:1 mg/kg
Administration:Oral gavage; 1 mg/kg; 14 days
Result:Had an effect on the social deficit in mice that received repeated PCP administration.
体外研究：
Blonanserin exerts some blockade of?α1-adrenergic receptors?(Ki=26.7?nM) and also shows significant affinity for the?D3?receptor?(Ki=0.494 nM). Blonanserin possesses low affinity for the?sigma receptor?(IC50=286 nM), but lacks significant?affinity?for numerous other sites including the?5-HT1A,?5-HT3,?D1,?α2-adrenergic,?β-adrenergic,?H1, and?mACh receptors?and the?monoamine transporters.
产品资料
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